UniProt Accession

 GIPC1_MOUSE; Q9Z0G0 

Genbank Protein ID

 AF089818; AF104358; AF061263; AK086506; BC003490 

Genbank Nucleotide ID

 AAC67550.1; AAD12262.1; AAC72311.1; BAC39680.1; AAH03490.1 

Protein Name

 PDZ domain-containing protein GIPC1 

Protein Synonyms/Alias

 GAIP C-terminus-interacting protein; RGS-GAIP-interacting protein; RGS19-interacting protein 1; SemaF cytoplasmic domain-associated protein 1; SEMCAP-1; Synectin 

Gene Name

 Gipc1 

Gene Synonyms/Alias

 Gipc; Rgs19ip1; Semcap1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
80	IEGFTNVKELYGKIA	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Inhibits endothelial cell migartion (in vitro). May be involved in G protein-linked signaling (By similarity). 

Sequence Annotation

 DOMAIN 133 213 PDZ.
 MOD_RES 225 225 Phosphoserine (By similarity).
 MOD_RES 232 232 Phosphoserine (By similarity).  

Keyword

 Complete proteome; Cytoplasm; Membrane; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 333 AA 

Protein Sequence

Gene Ontology

 GO:0005903; C:brush border; IEA:Compara.
 GO:0005938; C:cell cortex; IEA:Compara.
 GO:0005829; C:cytosol; IDA:MGI.
 GO:0043198; C:dendritic shaft; IDA:MGI.
 GO:0043197; C:dendritic spine; IDA:MGI.
 GO:0030139; C:endocytic vesicle; IEA:Compara.
 GO:0008021; C:synaptic vesicle; IDA:MGI.
 GO:0012506; C:vesicle membrane; IDA:MGI.
 GO:0005096; F:GTPase activator activity; TAS:MGI.
 GO:0043542; P:endothelial cell migration; IMP:MGI.
 GO:0007186; P:G-protein coupled receptor signaling pathway; TAS:MGI.
 GO:0014047; P:glutamate secretion; IMP:MGI.
 GO:0032435; P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process; IDA:BHF-UCL.
 GO:0030511; P:positive regulation of transforming growth factor beta receptor signaling pathway; IDA:BHF-UCL.
 GO:0006605; P:protein targeting; IMP:MGI.
 GO:0031647; P:regulation of protein stability; IDA:BHF-UCL.
 GO:0048167; P:regulation of synaptic plasticity; IMP:MGI.
 GO:0007268; P:synaptic transmission; IMP:MGI. 

Interpro

 IPR001478; PDZ.
 IPR017379; UCP038083_PDZ. 

Pfam

 PF00595; PDZ 

SMART

 SM00228; PDZ 

PROSITE

 PS50106; PDZ 

PRINTS