UniProt Accession

 CBX1_MOUSE; P83917; P23197 

Genbank Protein ID

 X56690; AK014215 

Genbank Nucleotide ID

 CAA40018.1; BAB29211.1 

Protein Name

 Chromobox protein homolog 1 

Protein Synonyms/Alias

 Heterochromatin protein 1 homolog beta; HP1 beta; Heterochromatin protein p25; M31; Modifier 1 protein 

Gene Name

 Cbx1 

Gene Synonyms/Alias

 Cbx 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
8	MGKKQNKKKVEEVLE	acetylation	[1]
9	GKKQNKKKVEEVLEE	acetylation	[2]
150	EADLVPAKEANVKCP	ubiquitination	[3]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
 Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
 J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane. 

Sequence Annotation

 DOMAIN 21 79 Chromo 1.
 DOMAIN 117 175 Chromo 2; shadow subtype.
 BINDING 21 21 Histone H3K9me2.
 BINDING 23 23 Histone H3A7.
 BINDING 40 40 Histone H3A7.
 BINDING 42 42 Histone H3A7.
 BINDING 42 42 Histone H3K9me2.
 BINDING 45 45 Histone H3K9me2.
 BINDING 58 58 Histone H3A7.
 BINDING 60 60 Histone H3A7.
 BINDING 125 125 PxVxL motif.
 BINDING 126 126 PxVxL motif.
 BINDING 135 135 PxVxL motif.
 BINDING 146 146 PxVxL motif.
 BINDING 163 163 PxVxL motif.
 BINDING 167 167 PxVxL motif.
 BINDING 168 168 PxVxL motif.
 BINDING 170 170 PxVxL motif.
 MOD_RES 89 89 Phosphoserine (By similarity).
 MOD_RES 91 91 Phosphoserine (By similarity).
 MOD_RES 175 175 Phosphoserine (By similarity).  

Keyword

 3D-structure; Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Repeat; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 185 AA 

Protein Sequence

Gene Ontology

 GO:0005721; C:centromeric heterochromatin; IDA:MGI.
 GO:0010369; C:chromocenter; IDA:MGI.
 GO:0001939; C:female pronucleus; IDA:MGI.
 GO:0001940; C:male pronucleus; IDA:MGI.
 GO:0005819; C:spindle; IEA:Compara.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:MGI. 

Interpro

 IPR017984; Chromo_dom_subgr.
 IPR023780; Chromo_domain.
 IPR000953; Chromo_domain/shadow.
 IPR008251; Chromo_shadow_dom.
 IPR016197; Chromodomain-like.
 IPR023779; Chromodomain_CS. 

Pfam

 PF00385; Chromo
 PF01393; Chromo_shadow 

SMART

 SM00298; CHROMO
 SM00300; ChSh 

PROSITE

 PS00598; CHROMO_1
 PS50013; CHROMO_2 

PRINTS

 PR00504; CHROMODOMAIN.