UniProt Accession

 AASD1_HUMAN; Q9BTE6; B4DI73 

Genbank Protein ID

 AK295447; CR608238; AC055866; CH471152; BC004172; BC019324 

Genbank Nucleotide ID

 BAG58385.1; EAW60903.1; AAH04172.1; AAH19324.1 

Protein Name

 Alanyl-tRNA editing protein Aarsd1 

Protein Synonyms/Alias

 Alanyl-tRNA synthetase domain-containing protein 1 

Gene Name

 AARSD1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
35	TEGSNGKKEVLSGFQ	ubiquitination	[1]
126	ADHLFKLKTTSWELG	ubiquitination	[1, 2]
161	IEQSVNEKIRDRLPV	ubiquitination	[1, 2]
248	LSGNRVLKWMERSHG	ubiquitination	[1]
258	ERSHGTEKALTALLK	ubiquitination	[1]
265	KALTALLKCGAEDHV	ubiquitination	[1]
276	EDHVEAVKKLQNSTK	ubiquitination	[1]
277	DHVEAVKKLQNSTKI	ubiquitination	[1]
283	KKLQNSTKILQKNNL	ubiquitination	[1]
287	NSTKILQKNNLNLLR	ubiquitination	[1, 3]
376	VAEVLEGKGAGKKGR	ubiquitination	[1, 2]
380	LEGKGAGKKGRFQGK	ubiquitination	[1]
381	EGKGAGKKGRFQGKA	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

 Functions in trans to edit the amino acid moiety from incorrectly charged tRNA(Ala) (By similarity). 

Sequence Annotation

 METAL 109 109 Zinc (Potential).
 METAL 113 113 Zinc (Potential).
 METAL 209 209 Zinc (Potential).
 METAL 213 213 Zinc (Potential).
 MOD_RES 409 409 Phosphoserine (By similarity).  

Keyword

 Alternative splicing; Complete proteome; Cytoplasm; Metal-binding; Phosphoprotein; Protein biosynthesis; Reference proteome; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 412 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0004813; F:alanine-tRNA ligase activity; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0003676; F:nucleic acid binding; IEA:InterPro.
 GO:0006419; P:alanyl-tRNA aminoacylation; IEA:InterPro. 

Interpro

 IPR018165; Ala-tRNA-synth_IIc_core.
 IPR018164; Ala-tRNA-synth_IIc_N.
 IPR018163; Thr/Ala-tRNA-synth_IIc_edit.
 IPR012947; tRNA_SAD. 

Pfam

 PF01411; tRNA-synt_2c
 PF07973; tRNA_SAD 

SMART

 SM00863; tRNA_SAD 

PROSITE

 PS50860; AA_TRNA_LIGASE_II_ALA 

PRINTS