UniProt Accession

 SDCB1_HUMAN; O00560; B2R5Q7; B4DUH3; B7ZLN2; O00173; O43391; Q14CP2 

Genbank Protein ID

 AF006636; AF000652; U83463; AK300647; AK312274; AC068522; CH471068; BC113674; BC113676; BC143915; BC143916 

Genbank Nucleotide ID

 AAC52050.1; AAB97144.1; AAB51246.1; BAG62335.1; BAG35204.1; EAW86814.1; AAI13675.1; AAI13677.1; AAI43916.1; AAI43917.1 

Protein Name

 Syntenin-1 

Protein Synonyms/Alias

 Melanoma differentiation-associated protein 9; MDA-9; Pro-TGF-alpha cytoplasmic domain-interacting protein 18; TACIP18; Scaffold protein Pbp1; Syndecan-binding protein 1 

Gene Name

 SDCBP 

Gene Synonyms/Alias

 MDA9; SYCL 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
14	LEDLKVDKVIQAQTA	ubiquitination	[1]
178	DKAHKVLKQAFGEKI	ubiquitination	[1]
184	LKQAFGEKITMTIRD	ubiquitination	[1]
222	GKITSIVKDSSAARN	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Seems to function as an adapter protein. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway. 

Sequence Annotation

 DOMAIN 114 193 PDZ 1.
 DOMAIN 198 273 PDZ 2.
 MOD_RES 2 2 N-acetylserine.  

Keyword

 3D-structure; Acetylation; Alternative splicing; Cell junction; Cell membrane; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Endoplasmic reticulum; Membrane; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 298 AA 

Protein Sequence

Gene Ontology

 GO:0005912; C:adherens junction; NAS:UniProtKB.
 GO:0005856; C:cytoskeleton; NAS:UniProtKB.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0070062; C:extracellular vesicular exosome; IDA:UniProtKB.
 GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.
 GO:0005895; C:interleukin-5 receptor complex; ISS:UniProtKB.
 GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; NAS:UniProtKB.
 GO:0008093; F:cytoskeletal adaptor activity; NAS:UniProtKB.
 GO:0005137; F:interleukin-5 receptor binding; ISS:UniProtKB.
 GO:0045545; F:syndecan binding; NAS:UniProtKB.
 GO:0030036; P:actin cytoskeleton organization; NAS:UniProtKB.
 GO:0007411; P:axon guidance; TAS:Reactome.
 GO:0035556; P:intracellular signal transduction; NAS:UniProtKB.
 GO:0046330; P:positive regulation of JNK cascade; IC:BHF-UCL.
 GO:0042327; P:positive regulation of phosphorylation; IDA:BHF-UCL.
 GO:0006612; P:protein targeting to membrane; NAS:UniProtKB.
 GO:0007265; P:Ras protein signal transduction; IEA:Compara.
 GO:0006930; P:substrate-dependent cell migration, cell extension; NAS:UniProtKB.
 GO:0007268; P:synaptic transmission; NAS:UniProtKB. 

Interpro

 IPR001478; PDZ. 

Pfam

 PF00595; PDZ 

SMART

 SM00228; PDZ 

PROSITE

 PS50106; PDZ 

PRINTS