| Tag | Content |
|---|
| CPLM ID | CPLM-013850 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Leucine-rich repeat-containing protein 59 |
Protein Synonyms/Alias | Protein p34 |
Gene Name | Lrrc59 |
Gene Synonyms/Alias | Rbp34 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 73 | KLDLSKNKLQQLPAD | acetylation | [1] | | 108 | PVSFAQLKNLKWLDL | acetylation | [1] | | 111 | FAQLKNLKWLDLKDN | acetylation | [1] | | 116 | NLKWLDLKDNPLDPV | acetylation | [1] | | 135 | AGDCLDEKQCKQCAN | acetylation | [1] | | 149 | NKVLQHMKAVQADQE | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Required for nuclear import of FGF1, but not that of FGF2. Might regulate nuclear import of exogenous FGF1 by facilitating interaction with the nuclear import machinery and by transporting cytosolic FGF1 to, and possibly through, the nuclear pores (By similarity). |
Sequence Annotation | REPEAT 10 31 LRR 1.
REPEAT 40 62 LRR 2.
REPEAT 63 84 LRR 3.
REPEAT 86 107 LRR 4.
REPEAT 109 128 LRR 5.
MOD_RES 23 23 Phosphoserine (By similarity).
MOD_RES 25 25 Phosphoserine (By similarity). |
Keyword | Coiled coil; Complete proteome; Endoplasmic reticulum; Leucine-rich repeat; Membrane; Microsome; Nucleus; Phosphoprotein; Reference proteome; Repeat; Signal-anchor; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 307 AA |
Protein Sequence | MTKTGSKGGN LRDKLDGNEL DLSLSDLNEV PVKELAALPK ATVLDLSCNK LSTLPSDFCG 60
LTHLVKLDLS KNKLQQLPAD FGRLVNLQHL DLLNNRLVTL PVSFAQLKNL KWLDLKDNPL 120
DPVLAKVAGD CLDEKQCKQC ANKVLQHMKA VQADQERERQ RRLEVEREAE KKREAKQQAK 180
EAKERELRKR EKAEEKERRR KEYDAQKASK REQEKKPKKE TNQAPKSKSG SRPRKPPPRK 240
HNRSWAVLKG LLLLLLLCVA GGLVVCRVTG LQQQPLCTSV NAIYDNAVQG LRHHEILQWV 300
LQTDSQQ 307 |
Gene Ontology | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0042645; C:mitochondrial nucleoid; IEA:Compara. GO:0005635; C:nuclear envelope; IEA:UniProtKB-SubCell. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |