CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016212
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Regulating synaptic membrane exocytosis protein 1 
Protein Synonyms/Alias
 Rab-3-interacting molecule 1; RIM 1; Rab-3-interacting protein 2 
Gene Name
 RIMS1 
Gene Synonyms/Alias
 KIAA0340; RAB3IP2; RIM1; Nbla00761 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
1463ESGHKKLKSTIQRSTubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Rab effector involved in exocytosis. May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short- term synaptic plasticity (By similarity). 
Sequence Annotation
 DOMAIN 22 182 RabBD.
 DOMAIN 605 691 PDZ.
 DOMAIN 744 850 C2 1.
 DOMAIN 1538 1640 C2 2.
 ZN_FING 110 170 FYVE-type.
 MOD_RES 324 324 Phosphoserine (By similarity).
 MOD_RES 881 881 Phosphoserine (By similarity).
 MOD_RES 977 977 Phosphoserine (By similarity).
 MOD_RES 1252 1252 Phosphoserine (By similarity).
 MOD_RES 1254 1254 Phosphothreonine (By similarity).
 MOD_RES 1256 1256 Phosphoserine (By similarity).
 MOD_RES 1677 1677 Phosphoserine.
 MOD_RES 1680 1680 Phosphoserine.
 MOD_RES 1683 1683 Phosphoserine.
 MOD_RES 1692 1692 Phosphoserine.  
Keyword
 3D-structure; Alternative splicing; Cell junction; Cell membrane; Complete proteome; Cone-rod dystrophy; Disease mutation; Exocytosis; Membrane; Metal-binding; Neurotransmitter transport; Phosphoprotein; Reference proteome; Repeat; Sensory transduction; Synapse; Transport; Vision; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1692 AA 
Protein Sequence
MSSAVGPRGP RPPTVPPPMQ ELPDLSHLTE EERNIIMAVM DRQKEEEEKE EAMLKCVVRD 60
MAKPAACKTP RNAENQPHQP SPRLHQQFES YKEQVRKIGE EARRYQGEHK DDAPTCGICH 120
KTKFADGCGH LCSYCRTKFC ARCGGRVSLR SNNEDKVVMW VCNLCRKQQE ILTKSGAWFF 180
GSGPQQTSQD GTLSDTATGA GSEVPREKKA RLQERSRSQT PLSTAAASSQ DAAPPSAPPD 240
RSKGAEPSQQ ALGPEQKQAS SRSRSEPPRE RKKTPGLSEQ NGKGALKSER KRVPKTSAQP 300
VEGAVEERER KERRESRRLE KGRSQDYPDT PEKRDEGKAA DEEKQRKEED YQTRYRSDPN 360
LARYPVKPPP EEQQMRMHAR VSRARHERRH SDVALPRTEA GAALPEGKAG KRAPAAARAS 420
PPDSPRAYSA ERTAETRAPG AKQLTNHSPP APRHGPVPAE APELKAQEPL RKQSRLDPSS 480
AVLMRKAKRE KVETMLRNDS LSSDQSESVR PSPPKPHRSK RGGKKRQMSV SSSEEEGVST 540
PEYTSCEDVE LESESVSEKG DLDYYWLDPA TWHSRETSPI SSHPVTWQPS KEGDRLIGRV 600
ILNKRTTMPK DSGALLGLKV VGGKMTDLGR LGAFITKVKK GSLADVVGHL RAGDEVLEWN 660
GKPLPGATNE EVYNIILESK SEPQVEIIVS RPIGDIPRIP ESSHPPLESS SSSFESQKME 720
RPSISVISPT SPGALKDAPQ VLPGQLSVKL WYDKVGHQLI VNVLQATDLP ARVDGRPRNP 780
YVKMYFLPDR SDKSKRRTKT VKKILEPKWN QTFVYSHVHR RDFRERMLEI TVWDQPRVQE 840
EESEFLGEIL IELETALLDD EPHWYKLQTH DESSLPLPQP SPFMPRRHIH GESSSKKLQR 900
SQRISDSDIS DYEVDDGIGV VPPVGYRSSA RESKSTTLTV PEQQRTTHHR SRSVSPHRGN 960
DQGKPRSRLP NVPLQRSLDE IHPTRRSRSP TRHHDASRSP VDHRTRDVDS QYLSEQDSEL 1020
LMLPRAKRGR SAECLHTTRH LVRHYKTLPP KMPLLQSSSH WNIYSSILPA HTKTKSVTRQ 1080
DISLHHECFN STVLRFTDEI LVSELQPFLD RARSASTNCL RPDTSLHSPE RERGRWSPSL 1140
DRRRPPSPRI QIQHASPEND RHSRKSERSS IQKQTRKGTA SDAERVLPTC LSRRGHAAPR 1200
ATDQPVIRGK HPARSRSSEH SSIRTLCSMH HLVPGGSAPP SPLLTRMHRQ RSPTQSPPAD 1260
TSFSSRRGRQ LPQVPVRSGS IEQASLVVEE RTRQMKMKVH RFKQTTGSGS SQELDREQYS 1320
KYNIHKDQYR SCDNVSAKSS DSDVSDVSAI SRTSSASRLS STSFMSEQSE RPRGRISSFT 1380
PKMQGRRMGT SGRSIMKSTS VSGEMYTLEH NDGSQSDTAV GTVGAGGKKR RSSLSAKVVA 1440
IVSRRSRSTS QLSQTESGHK KLKSTIQRST ETGMAAEMRK MVRQPSREST DGSINSYSSE 1500
GNLIFPGVRL GADSQFSDFL DGLGPAQLVG RQTLATPAMG DIQIGMEDKK GQLEVEVIRA 1560
RSLTQKPGSK STPAPYVKVY LLENGACIAK KKTRIARKTL DPLYQQSLVF DESPQGKVLQ 1620
VIVWGDYGRM DHKCFMGVAQ ILLEELDLSS MVIGWYKLFP PSSLVDPTLT PLTRRASQSS 1680
LESSTGPPCI RS 1692 
Gene Ontology
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0042734; C:presynaptic membrane; ISS:UniProtKB.
 GO:0005083; F:small GTPase regulator activity; TAS:UniProtKB.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0017156; P:calcium ion-dependent exocytosis; TAS:UniProtKB.
 GO:0048791; P:calcium ion-dependent exocytosis of neurotransmitter; IEA:Compara.
 GO:0006944; P:cellular membrane fusion; NAS:UniProtKB.
 GO:0014047; P:glutamate secretion; TAS:Reactome.
 GO:0006886; P:intracellular protein transport; IEA:InterPro.
 GO:0006461; P:protein complex assembly; IDA:UniProtKB.
 GO:0045055; P:regulated secretory pathway; NAS:UniProtKB.
 GO:0048169; P:regulation of long-term neuronal synaptic plasticity; IEA:Compara.
 GO:0042391; P:regulation of membrane potential; IEA:Compara.
 GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
 GO:0016079; P:synaptic vesicle exocytosis; TAS:UniProtKB.
 GO:0007601; P:visual perception; IEA:UniProtKB-KW. 
Interpro
 IPR000008; C2_Ca-dep.
 IPR008973; C2_Ca/lipid-bd_dom_CaLB.
 IPR018029; C2_membr_targeting.
 IPR001478; PDZ.
 IPR010911; Rab-bd_domain.
 IPR017455; Znf_FYVE-rel.
 IPR011011; Znf_FYVE_PHD.
 IPR013083; Znf_RING/FYVE/PHD. 
Pfam
 PF00168; C2
 PF00595; PDZ 
SMART
 SM00239; C2
 SM00228; PDZ 
PROSITE
 PS50004; C2
 PS50106; PDZ
 PS50916; RABBD
 PS50178; ZF_FYVE 
PRINTS