CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018495
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Probable lipid phosphate phosphatase PPAPDC3 
Protein Synonyms/Alias
 Nuclear envelope transmembrane protein 39; Phosphatidic acid phosphatase type 2 domain-containing protein 3 
Gene Name
 Ppapdc3 
Gene Synonyms/Alias
 Net39 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
30LSLNQPPKGTQEPRSubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Plays a role as negative regulator of myoblast differentiation, in part through effects on MTOR signaling. Has no detectable enzymatic activity. Knockdown in myoblasts strongly promotes differentiation, whereas overexpression represses myogenesis. 
Sequence Annotation
 REGION 70 91 interaction with MTOR.  
Keyword
 Complete proteome; Endoplasmic reticulum; Hydrolase; Membrane; Nucleus; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 271 AA 
Protein Sequence
MPASQSRARA RDRNNVLNRA EFLSLNQPPK GTQEPRSSGR KASGPSTQPP PSSDGARERR 60
QSQQLPEEDC MQLNPSFKGI AFNSLLAIDI CMSKRLGVCA GRAASWASAR SMVKLIGITG 120
HGIPWIGGTI LCLVRSSTLA GQEVLMNLLL ALLLDIMTVA GVQKLIKRRG PYETSPGLLD 180
YLTMDIYAFP AGHASRAAMV SKFFLSHLVL AVPLRVLLVL WAFCVGLSRV MIGRHHITDV 240
ISGFIIGYFQ FRLVELVWMS SNTCQMLISA W 271 
Gene Ontology
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005635; C:nuclear envelope; IDA:MGI.
 GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
 GO:0008152; P:metabolic process; IEA:GOC.
 GO:0010832; P:negative regulation of myotube differentiation; IMP:MGI. 
Interpro
 IPR016118; P_Acid_Pase/Cl_peroxidase_N.
 IPR000326; P_Acid_Pase_2/haloperoxidase. 
Pfam
 PF01569; PAP2 
SMART
 SM00014; acidPPc 
PROSITE
  
PRINTS