CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012848
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zinc finger protein ZXDC 
Protein Synonyms/Alias
 ZXD-like zinc finger protein 
Gene Name
 ZXDC 
Gene Synonyms/Alias
 ZXDL 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
260YNLKAHMKGHEQESLubiquitination[1]
282ERFPTHAKLSSHQRSubiquitination[1]
397CPVEGCGKSFTRAEHubiquitination[1]
465CNRLFTSKHSMKAHMubiquitination[1]
660PELLAPIKVEPDSPSsumoylation[2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Sumoylation of the zinc finger protein ZXDC enhances the function of its transcriptional activation domain.
 Jambunathan S, Fontes JD.
 Biol Chem. 2007 Sep;388(9):965-72. [PMID: 17696781] 
Functional Description
 Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes. 
Sequence Annotation
 ZN_FING 175 199 C2H2-type 1.
 ZN_FING 208 232 C2H2-type 2.
 ZN_FING 238 262 C2H2-type 3.
 ZN_FING 268 290 C2H2-type 4.
 ZN_FING 297 321 C2H2-type 5.
 ZN_FING 328 352 C2H2-type 6.
 ZN_FING 358 382 C2H2-type 7.
 ZN_FING 388 412 C2H2-type 8.
 ZN_FING 418 442 C2H2-type 9.
 ZN_FING 451 476 C2H2-type 10.
 REGION 579 688 Required for transcriptional activation.
 REGION 781 858 Interaction with CIITA.
 CROSSLNK 660 660 Glycyl lysine isopeptide (Lys-Gly)  
Keyword
 Activator; Alternative splicing; Complete proteome; Isopeptide bond; Metal-binding; Nucleus; Polymorphism; Reference proteome; Repeat; Transcription; Transcription regulation; Ubl conjugation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 858 AA 
Protein Sequence
MDLPALLPAP TARGGQHGGG PGPLRRAPAP LGASPARRRL LLVRGPEDGG PGARPGEASG 60
PSPPPAEDDS DGDSFLVLLE VPHGGAAAEA AGSQEAEPGS RVNLASRPEQ GPSGPAAPPG 120
PGVAPAGAVT ISSQDLLVRL DRGVLALSAP PGPATAGAAA PRRAPQASGP STPGYRCPEP 180
QCALAFAKKH QLKVHLLTHG GGQGRRPFKC PLEGCGWAFT TSYKLKRHLQ SHDKLRPFGC 240
PVGGCGKKFT TVYNLKAHMK GHEQESLFKC EVCAERFPTH AKLSSHQRSH FEPERPYKCD 300
FPGCEKTFIT VSALFSHNRA HFREQELFSC SFPGCSKQYD KACRLKIHLR SHTGERPFIC 360
DSDSCGWTFT SMSKLLRHRR KHDDDRRFTC PVEGCGKSFT RAEHLKGHSI THLGTKPFEC 420
PVEGCCARFS ARSSLYIHSK KHVQDVGAPK SRCPVSTCNR LFTSKHSMKA HMVRQHSRRQ 480
DLLPQLEAPS SLTPSSELSS PGQSELTNMD LAALFSDTPA NASGSAGGSD EALNSGILTI 540
DVTSVSSSLG GNLPANNSSL GPMEPLVLVA HSDIPPSLDS PLVLGTAATV LQQGSFSVDD 600
VQTVSAGALG CLVALPMKNL SDDPLALTSN SNLAAHITTP TSSSTPRENA SVPELLAPIK 660
VEPDSPSRPG AVGQQEGSHG LPQSTLPSPA EQHGAQDTEL SAGTGNFYLE SGGSARTDYR 720
AIQLAKEKKQ RGAGSNAGAS QSTQRKIKEG KMSPPHFHAS QNSWLCGSLV VPSGGRPGPA 780
PAAGVQCGAQ GVQVQLVQDD PSGEGVLPSA RGPATFLPFL TVDLPVYVLQ EVLPSSGGPA 840
GPEATQFPGS TINLQDLQ 858 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003676; F:nucleic acid binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IMP:UniProtKB.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:UniProtKB.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
 PF00096; zf-C2H2 
SMART
 SM00355; ZnF_C2H2 
PROSITE
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS