UniProt Accession

 NMNA2_MOUSE; Q8BNJ3 

Genbank Protein ID

 AK129155; AK083532 

Genbank Nucleotide ID

 BAC97965.1; BAC38943.1 

Protein Name

 Nicotinamide mononucleotide adenylyltransferase 2 

Protein Synonyms/Alias

 NMN adenylyltransferase 2; Nicotinate-nucleotide adenylyltransferase 1; NaMN adenylyltransferase 1 

Gene Name

 Nmnat2 

Gene Synonyms/Alias

 Kiaa0479 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
57	PVHDSYGKQGLVSSR	ubiquitination	[1]
155	TAAKILGKVGESLSR	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency. Cannot use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity prefers NAD(+), NADH and NAAD as substrates and degrades nicotinic acid adenine dinucleotide phosphate (NHD) less effectively. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NAADP(+) (By similarity). 

Sequence Annotation

 NP_BIND 15 24 ATP (Potential).
 NP_BIND 269 274 ATP (Potential).
 BINDING 16 16 Substrate (By similarity).
 BINDING 55 55 Substrate (By similarity).
 BINDING 202 202 Substrate (By similarity).  

Keyword

 ATP-binding; Complete proteome; Cytoplasm; Golgi apparatus; NAD; Nucleotide-binding; Nucleotidyltransferase; Pyridine nucleotide biosynthesis; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 307 AA 

Protein Sequence

Gene Ontology

 GO:0005794; C:Golgi apparatus; IDA:MGI.
 GO:0005770; C:late endosome; IDA:MGI.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0045202; C:synapse; IDA:MGI.
 GO:0005802; C:trans-Golgi network; IDA:MGI.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0000309; F:nicotinamide-nucleotide adenylyltransferase activity; IEA:EC.
 GO:0004515; F:nicotinate-nucleotide adenylyltransferase activity; IEA:EC.
 GO:0009435; P:NAD biosynthetic process; IEA:UniProtKB-UniPathway. 

Interpro

 IPR004821; Cyt_trans-like.
 IPR005248; NAMN_adtrnsfrase.
 IPR014729; Rossmann-like_a/b/a_fold. 

Pfam

 PF01467; CTP_transf_2 

SMART

  

PROSITE

  

PRINTS