CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040003
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Dual-specificity tyrosine-phosphorylation-regulated kinase 4 
Protein Synonyms/Alias
  
Gene Name
 DYRK4 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
532PRPQTLRKSNSFFPSubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 545 AA 
Protein Sequence
MQLLPPPIRT GTKTQMDAKK PRKCDLTPFL VLKARKKQKF TSAKVGSKLS VQIQKPPSNI 60
KNSRMTQVFH KNTSVTSLPF VDTKGKKNTV SFPHISKKVL LKSSLLYQEN QAHNQMPASE 120
LKASEIPFHP SIKTQDPKAE EKSPKKQKVT LTAAEALKLF KNQLSPYEQS EILGYAELWF 180
LGLEAKKLDT APEKFSKTSF DDEHGFYLKV LHDHIAYRYE VLETIGKGSF GQVAKCLDHK 240
NNELVALKII RNKKRFHQQA LMELKILEAL RKKDKDNTYN VVHMKDFFYF RNHFCITFEL 300
LGINLYELMK NNNFQGFSLS IVRRFTLSVL KCLQMLSVEK IIHCDLKPEN IVLYQKGQAS 360
VKVIDFGSSC YEHQKVYTYI QSRFYRSPEV ILGHPYDVAI DMWSLGCITA ELYTGYPLFP 420
GENEVEQLAC IMEVLGLPPA GFIQTASRRQ TFFDSKGFPK NITNNRGKKR YPDSKDLTMV 480
LKTYDTSFLD FLRRCLVWEP SLRMTPDQAL KHAWIHQSRN LKPQPRPQTL RKSNSFFPSE 540
TRKDK 545 
Gene Ontology
 GO:0005794; C:Golgi apparatus; IDA:HPA.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:InterPro. 
Interpro
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 
Pfam
 PF00069; Pkinase 
SMART
 SM00220; S_TKc 
PROSITE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS