UniProt Accession

 KCAB2_MOUSE; P62482; P97381; Q60942; Q64284 

Genbank Protein ID

 L48983; U65592; U31908; BC039178 

Genbank Nucleotide ID

 AAB00829.1; AAB37263.1; AAA75174.1; AAH39178.1 

Protein Name

 Voltage-gated potassium channel subunit beta-2 

Protein Synonyms/Alias

 K(+) channel subunit beta-2; Kv-beta-2; Neuroimmune protein F5 

Gene Name

 Kcnab2 

Gene Synonyms/Alias

 Ckbeta2; I2rf5; Kcnb3 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
104	VVLGNIIKKKGWRRS	ubiquitination	[1]
124	TKIFWGGKAETERGL	ubiquitination	[1]
141	KHIIEGLKASLERLQ	ubiquitination	[1]
268	PYSRASLKGYQWLKD	ubiquitination	[1, 2]
274	LKGYQWLKDKILSEE	ubiquitination	[1]
276	GYQWLKDKILSEEGR	ubiquitination	[1]
290	RRQQAKLKELQAIAE	ubiquitination	[1]
358	IDSILGNKPYSKKDY	ubiquitination	[1]
362	LGNKPYSKKDYRS**	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 

Functional Description

 Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. 

Sequence Annotation

 NP_BIND 56 57 NADP (By similarity).
 NP_BIND 188 189 NADP (By similarity).
 NP_BIND 243 248 NADP (By similarity).
 NP_BIND 323 329 NADP (By similarity).
 BINDING 63 63 NADP (By similarity).
 BINDING 85 85 NADP (By similarity).
 BINDING 90 90 NADP (By similarity).
 BINDING 214 214 NADP (By similarity).
 BINDING 254 254 NADP (By similarity).
 MOD_RES 9 9 Phosphoserine.
 MOD_RES 20 20 Phosphoserine.
 MOD_RES 25 25 Phosphotyrosine.
 MOD_RES 124 124 N6-acetyllysine (By similarity).
 MOD_RES 360 360 Phosphotyrosine.  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Ion channel; Ion transport; NADP; Phosphoprotein; Potassium; Potassium transport; Reference proteome; Transport; Voltage-gated channel. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 367 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:InterPro.
 GO:0044224; C:juxtaparanode region of axon; IDA:BHF-UCL.
 GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
 GO:0051291; P:protein heterooligomerization; IEA:Compara. 

Interpro

 IPR001395; Aldo/ket_red.
 IPR005983; K_chnl_volt-dep_bsu_KCNAB.
 IPR005399; K_chnl_volt-dep_bsu_KCNAB-rel.
 IPR005401; K_chnl_volt-dep_bsu_KCNAB2.
 IPR023210; NADP_OxRdtase_dom. 

Pfam

 PF00248; Aldo_ket_red 

SMART

  

PROSITE

  

PRINTS

 PR01579; KCNAB2CHANEL.
 PR01577; KCNABCHANNEL.