CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040560
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 E3 ubiquitin-protein ligase TRIM63 
Protein Synonyms/Alias
  
Gene Name
 Trim63 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
46CQHNLCRKCANDIFQubiquitination[1]
255QYREQLEKSTKLVETubiquitination[1]
258EQLEKSTKLVETAIQubiquitination[1]
291KSIVEASKGCQLGKTubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Metal-binding; Reference proteome; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 355 AA 
Protein Sequence
MDYKSSLIPD GNAMENLEKQ LICPICLEMF TKPVVILPCQ HNLCRKCAND IFQAANPYWT 60
NRGGSVSMSG GRFRCPSCRH EVIMDRHGVY GLQRNLLVEN IIDIYKQECS SRPLQKGSHP 120
MCKEHEDEKI NIYCLTCEVP TCSLCKVFGA HQACEVAPLQ SIFQGQKTEL SNCISMLVAG 180
NDRVQTIISQ LEDSCRVTKE NSHQVKEELS QKFDTLYAIL DEKKSELLQR ITQEQEEKLG 240
FIEALILQYR EQLEKSTKLV ETAIQSLDEP GGATFLSSAK QLIKSIVEAS KGCQLGKTEQ 300
GFENMDYFTL DLEHIAEALR AIDFGTDEEE EEEEFTEEEA DEEEGVTTEG KEEHQ 355 
Gene Ontology
 GO:0043292; C:contractile fiber; ISA:MGI.
 GO:0004842; F:ubiquitin-protein ligase activity; IDA:MGI.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006936; P:muscle contraction; ISA:MGI.
 GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; IDA:MGI.
 GO:0010468; P:regulation of gene expression; IMP:MGI.
 GO:0051384; P:response to glucocorticoid stimulus; IEA:Compara.
 GO:0070555; P:response to interleukin-1; IEA:Compara.
 GO:0014732; P:skeletal muscle atrophy; IEA:Compara. 
Interpro
 IPR017903; COS_domain.
 IPR000315; Znf_B-box.
 IPR001841; Znf_RING.
 IPR013083; Znf_RING/FYVE/PHD.
 IPR017907; Znf_RING_CS. 
Pfam
 PF00643; zf-B_box 
SMART
 SM00336; BBOX
 SM00184; RING 
PROSITE
 PS51262; COS
 PS50119; ZF_BBOX
 PS00518; ZF_RING_1
 PS50089; ZF_RING_2 
PRINTS