UniProt Accession

 Q3UZR8_MOUSE; Q3UZR8 

Genbank Protein ID

 AK133695; CH466529 

Genbank Nucleotide ID

 BAE21787.1; EDL19576.1 

Protein Name

 Eukaryotic translation initiation factor 2B, subunit 1 (Alpha) 

Protein Synonyms/Alias

  

Gene Name

 Eif2b1 

Gene Synonyms/Alias

 mCG_17141 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
258	KYKADTLKSVQTGQD	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

  

Sequence Annotation

  

Keyword

 Initiation factor; Protein biosynthesis. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 305 AA 

Protein Sequence

Gene Ontology

 GO:0005851; C:eukaryotic translation initiation factor 2B complex; IBA:RefGenome.
 GO:0005886; C:plasma membrane; ISO:MGI.
 GO:0019003; F:GDP binding; IEA:Compara.
 GO:0005525; F:GTP binding; IEA:Compara.
 GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:RefGenome.
 GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
 GO:0032057; P:negative regulation of translational initiation in response to stress; IEA:Compara.
 GO:0014003; P:oligodendrocyte development; IEA:Compara.
 GO:0006446; P:regulation of translational initiation; IBA:RefGenome.
 GO:0009749; P:response to glucose stimulus; IEA:Compara.
 GO:0009408; P:response to heat; IEA:Compara.
 GO:0043434; P:response to peptide hormone stimulus; IEA:Compara. 

Interpro

 IPR000649; IF-2B-related. 

Pfam

 PF01008; IF-2B 

SMART

  

PROSITE

  

PRINTS