UniProt Accession

 NID2_RAT; B5DFC9; Q5M812 

Genbank Protein ID

 CH474061; BC088325; BC169012 

Genbank Nucleotide ID

 EDL86201.1; AAH88325.1; AAI69012.1 

Protein Name

 Nidogen-2 

Protein Synonyms/Alias

 NID-2 

Gene Name

 Nid2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
237	RGEADDLKREALYFS	acetylation	[1]
1292	NRRILINKDIGLPNG	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Cell adhesion glycoprotein. Might be involved in osteoblast differentiation. It probably has a role in cell- extracellular matrix interactions (By similarity). 

Sequence Annotation

 DOMAIN 108 274 NIDO.
 DOMAIN 500 540 EGF-like 1.
 DOMAIN 544 774 Nidogen G2 beta-barrel.
 DOMAIN 775 816 EGF-like 2.
 DOMAIN 817 859 EGF-like 3; calcium-binding (Potential).
 DOMAIN 864 907 EGF-like 4.
 DOMAIN 908 944 EGF-like 5; calcium-binding (Potential).
 DOMAIN 958 1026 Thyroglobulin type-1 1.
 DOMAIN 1037 1105 Thyroglobulin type-1 2.
 REPEAT 1175 1218 LDL-receptor class B 1.
 REPEAT 1219 1261 LDL-receptor class B 2.
 REPEAT 1262 1306 LDL-receptor class B 3.
 REPEAT 1307 1348 LDL-receptor class B 4.
 CARBOHYD 674 674 N-linked (GlcNAc...) (By similarity).
 CARBOHYD 719 719 N-linked (GlcNAc...) (Potential).
 DISULFID 504 517 By similarity.
 DISULFID 511 526 By similarity.
 DISULFID 528 539 By similarity.
 DISULFID 779 792 By similarity.
 DISULFID 786 802 By similarity.
 DISULFID 804 815 By similarity.
 DISULFID 821 834 By similarity.
 DISULFID 828 843 By similarity.
 DISULFID 845 858 By similarity.
 DISULFID 868 883 By similarity.
 DISULFID 875 893 By similarity.
 DISULFID 895 906 By similarity.
 DISULFID 912 923 By similarity.
 DISULFID 917 932 By similarity.
 DISULFID 961 984 By similarity.
 DISULFID 995 1002 By similarity.
 DISULFID 1004 1026 By similarity.
 DISULFID 1040 1064 By similarity.
 DISULFID 1075 1082 By similarity.
 DISULFID 1084 1105 By similarity.  

Keyword

 Alternative splicing; Basement membrane; Calcium; Cell adhesion; Complete proteome; Disulfide bond; EGF-like domain; Extracellular matrix; Glycoprotein; Reference proteome; Repeat; Secreted; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 1396 AA 

Protein Sequence

Gene Ontology

 GO:0005604; C:basement membrane; IEA:UniProtKB-SubCell.
 GO:0009986; C:cell surface; IDA:UniProtKB.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0007160; P:cell-matrix adhesion; IEA:Compara. 

Interpro

 IPR011042; 6-blade_b-propeller_TolB-like.
 IPR000742; EG-like_dom.
 IPR001881; EGF-like_Ca-bd.
 IPR013032; EGF-like_CS.
 IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
 IPR018097; EGF_Ca-bd_CS.
 IPR006605; G2_nidogen/fibulin_G2F.
 IPR009017; GFP.
 IPR023413; GFP_like.
 IPR000033; LDLR_classB_rpt.
 IPR003886; Nidogen_extracell_dom.
 IPR000716; Thyroglobulin_1. 

Pfam

 PF07645; EGF_CA
 PF07474; G2F
 PF00058; Ldl_recept_b
 PF06119; NIDO
 PF00086; Thyroglobulin_1 

SMART

 SM00181; EGF
 SM00179; EGF_CA
 SM00682; G2F
 SM00135; LY
 SM00539; NIDO
 SM00211; TY 

PROSITE

 PS00010; ASX_HYDROXYL
 PS00022; EGF_1
 PS01186; EGF_2
 PS50026; EGF_3
 PS01187; EGF_CA
 PS51120; LDLRB
 PS51220; NIDO
 PS50993; NIDOGEN_G2
 PS00484; THYROGLOBULIN_1_1
 PS51162; THYROGLOBULIN_1_2 

PRINTS