| Tag | Content |
|---|
| CPLM ID | CPLM-018218 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Voltage-dependent calcium channel gamma-8 subunit |
Protein Synonyms/Alias | Neuronal voltage-gated calcium channel gamma-8 subunit; Transmembrane AMPAR regulatory protein gamma-8; TARP gamma-8 |
Gene Name | Cacng8 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 243 | QSRSDLLKAGGGAGG | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. |
Sequence Annotation | MOD_RES 251 251 Phosphoserine. |
Keyword | Calcium; Calcium channel; Calcium transport; Cell junction; Cell membrane; Complete proteome; Ion channel; Ion transport; Membrane; Phosphoprotein; Postsynaptic cell membrane; Reference proteome; Synapse; Transmembrane; Transmembrane helix; Transport; Voltage-gated channel. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 423 AA |
Protein Sequence | MESLKRWNEE RGLWCEKGVQ VLLTTIGAFS AFGLMTIAIS TDYWLYTRAL ICNTTNLTAG 60
DDGPPHRGGS GSSEKKDPGG LTHSGLWRIC CLEGLKRGVC VKINHFPEDT DYDHDSAEYL 120
LRVVRASSIF PILSAILLLL GGVCVAASRV YKSKRNIILG AGILFVAAGL SNIIGVIVYI 180
SANAGEPGPK RDEEKKNHYS YGWSFYFGGL SFILAEVIGV LAVNIYIERS REAHCQSRSD 240
LLKAGGGAGG SGGSGPSAIL RLPSYRFRYR RRSRSSSRGS SEASPSRDAS PGGPGGPGFA 300
STDISMYTLS RDPSKGSVAA GLASAGGGGS GAGVGAYGGA AGAAGGGGAG SERDRGSSAG 360
FLTLHNAFPK EAASGVTVTV TGPPAAPAPA PAPPAPAAPA PGTLSKEAAA SNTNTLNRKT 420
TPV 423 |
Gene Ontology | GO:0032281; C:alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex; ISS:UniProtKB. GO:0030054; C:cell junction; IEA:UniProtKB-KW. GO:0014069; C:postsynaptic density; IDA:UniProtKB. GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW. GO:0005262; F:calcium channel activity; IEA:UniProtKB-KW. GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW. GO:2000311; P:regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; IDA:UniProtKB. |
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PRINTS | |