UniProt Accession

 ELF3_HUMAN; P78545; B2R5Q6; Q6IAP8; Q7RU03; Q7Z3X2; Q8NFG2; Q99718 

Genbank Protein ID

 U73843; U73844; U97156; U66894; AF016295; AF017307; AF110184; BN000001; AF517841; CR457106; AK312273; BX537368; AL691482; CH471067; BC003569 

Genbank Nucleotide ID

 AAB65823.1; AAB65824.1; AAC51884.1; AAB58075.1; AAB96586.1; AAB67238.1; AAD45237.1; CAD29859.1; AAM70481.1; CAG33387.1; BAG35203.1; CAD97611.1; CAI14961.1; EAW91389.1; AAH03569.1 

Protein Name

 ETS-related transcription factor Elf-3 

Protein Synonyms/Alias

 E74-like factor 3; Epithelial-restricted with serine box; Epithelium-restricted Ets protein ESX; Epithelium-specific Ets transcription factor 1; ESE-1 

Gene Name

 ELF3 

Gene Synonyms/Alias

 ERT; ESX; JEN 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
82	WISYQVEKNKYDASA	ubiquitination	[1]
84	SYQVEKNKYDASAID	ubiquitination	[1, 2]
294	ELNEGLMKWENRHEG	ubiquitination	[1]
318	VAQLWGQKKKNSNMT	ubiquitination	[1]
328	NSNMTYEKLSRAMRY	ubiquitination	[1]
356	RLVYKFGKNSSGWKE	ubiquitination	[1]
362	GKNSSGWKEEEVLQS	ubiquitination	[1, 2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development (By similarity). 

Sequence Annotation

 DOMAIN 46 132 PNT.
 DNA_BIND 273 355 ETS.
 MOTIF 137 145 9aaTAD.  

Keyword

 3D-structure; Activator; Alternative splicing; Complete proteome; Cytoplasm; Developmental protein; Differentiation; DNA-binding; Inflammatory response; Nucleus; Polymorphism; Reference proteome; Repressor; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 371 AA 

Protein Sequence

Gene Ontology

 GO:0005794; C:Golgi apparatus; IDA:HPA.
 GO:0005634; C:nucleus; NAS:UniProtKB.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; NAS:UniProtKB.
 GO:0003713; F:transcription coactivator activity; IDA:UniProtKB.
 GO:0001824; P:blastocyst development; IEA:Compara.
 GO:0008544; P:epidermis development; NAS:UniProtKB.
 GO:0030855; P:epithelial cell differentiation; IEP:UniProtKB.
 GO:0030198; P:extracellular matrix organization; IEA:Compara.
 GO:0006954; P:inflammatory response; IEP:UniProtKB.
 GO:0060056; P:mammary gland involution; ISS:UniProtKB.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:UniProtKB.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:UniProtKB.
 GO:0006366; P:transcription from RNA polymerase II promoter; TAS:ProtInc. 

Interpro

 IPR017956; AT_hook_DNA-bd_motif.
 IPR000418; Ets_dom.
 IPR003118; Pointed_dom.
 IPR013761; SAM/pointed.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF00178; Ets
 PF02198; SAM_PNT 

SMART

 SM00384; AT_hook
 SM00413; ETS
 SM00251; SAM_PNT 

PROSITE

 PS00345; ETS_DOMAIN_1
 PS00346; ETS_DOMAIN_2
 PS50061; ETS_DOMAIN_3
 PS51433; PNT 

PRINTS

 PR00454; ETSDOMAIN.