| Tag | Content |
|---|
| CPLM ID | CPLM-024387 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | DENN domain-containing protein 5B |
Protein Synonyms/Alias | Rab6IP1-like protein |
Gene Name | Dennd5b |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 426 | KLKNMVLKDLANDKK | ubiquitination | [1] | | 433 | KDLANDKKNGNVPNN | ubiquitination | [1] | | 449 | VSVYELLKGSETIAR | ubiquitination | [1] | | 470 | RTGVTMEKIDLPASL | ubiquitination | [1] | | 480 | LPASLSEKEKDLKLQ | ubiquitination | [1] | | 485 | SEKEKDLKLQCEEAD | ubiquitination | [1] | | 543 | EQMQNFDKASFLSDQ | ubiquitination | [1] | | 613 | LRTSIYQKCSSLKEA | ubiquitination | [1] | | 618 | YQKCSSLKEAAQSIE | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Guanine nucleotide exchange factor (GEF) which may activate RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (By similarity). |
Sequence Annotation | DOMAIN 50 120 UDENN.
DOMAIN 187 375 DENN.
DOMAIN 498 574 dDENN.
DOMAIN 772 932 RUN 1.
DOMAIN 936 1044 PLAT.
DOMAIN 1118 1267 RUN 2.
MOD_RES 2 2 N-acetylserine (By similarity).
MOD_RES 1076 1076 Phosphoserine. |
Keyword | Acetylation; Complete proteome; Guanine-nucleotide releasing factor; Membrane; Phosphoprotein; Reference proteome; Repeat; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1274 AA |
Protein Sequence | MSGSSAAPGP GSGSSPAACR FAHYFVLCGI DADSGLEPDE LAGENFDQSP LRRTFKSKVL 60
AHYPQNIEWN PFDQDAVNML CMPKGLSFRT QADNKEPQFH SFIITREDGS RTYGFVLTFY 120
EEVTSKQICT AMQTLYQMHN AEQYSSVYAS SSCSMDSLAS SIDEGDATSL LKLQRYNSYD 180
INRDTLYVSK SICLITPLPF MQACKKFLFQ LHKAVTSQQP PPLPLESYIH NILYEVPLPP 240
PGRSLKFYGV YEPVICQRPG PNELPLSDYP LREACELLGL ENLVQVFTCV LLEMQTLLYS 300
QDYQRLMTVA EGITTLLFPF QWQHVYVPIL PASLLHFLDA PVPYLMGLQS KEGTDRSKLE 360
LPQEANLCFV DIDNHFIELP EEFPQFPNKV DFIQELSEVL LQFGIPPEGS LHSSESATKL 420
KNMVLKDLAN DKKNGNVPNN SVSVYELLKG SETIARLQAL AKRTGVTMEK IDLPASLSEK 480
EKDLKLQCEE ADLRDSQLNV QLREVFANRF TQMFADYEAF VIQTAQDMES WLTNREQMQN 540
FDKASFLSDQ PEPYLPFLSR FIETQMFATF IDNKIMSQWE EKDPLLRVFD SRIEKIRLYN 600
VRAPTLRTSI YQKCSSLKEA AQSIEQRLMK MDHTAIHPHL LDMKIGQGKY EQGFFPKLQS 660
DVLATGPANN NRWVSRSATA QRRKERLRQS SEHIGLDSDL REKYMQEARS LGKNLRQPKL 720
SDLSPAVIAQ TNWKFVEGLL KECRMKTKRM LVEKMGHEAV ELGHGEANIT GLEENTLIAS 780
LCDLLERIWS HGLLVKQGKS ALWSHLLQFQ DREEKQEHLT DSPVALGPER RKSDSGVMLP 840
TLRVSLIQDM RHIQNMTEIK TDVGRARAWI RLSLEKKLLS QHLKQLLSNQ PLTKKLYKRY 900
AFLRCEEERE QFLYHLLSLN AVDYFCFTSV FTTIMIPYRS VIIPIKKLSN AIITSNPWIC 960
VSGELGDTGV MQIPKNLLEM TFECQNLGKL TTVQIGHDNS GLLAKWLVDC VMVRNEITGH 1020
TYRFPCGRWL GKGVDDGSLE RILIGELMTS ASDEDLGKQC RTPPQQKSPT TTRRLSITSL 1080
TGKPAKPNAG QIQEGIGEAV NNIVKHFHKP EKERGSLTVL LCGENGLVAA LEQVFHHGFK 1140
SARIFHKNVF IWDFVEKAVA YFETTDQILD NEGDVLIQKP SSKTFCHYVN AINTAPRNIG 1200
KDGKFQILVC LGTRDHLLPQ WIPLLAECPA ITRMYEENAL LRDHMTVNSL IRILQTIQDF 1260
TIVLEGSLIK GVDV 1274 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0016020; C:membrane; IBA:RefGenome. GO:0017112; F:Rab guanyl-nucleotide exchange factor activity; ISS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |