CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-042642
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Plasma kallikrein heavy chain 
Protein Synonyms/Alias
  
Gene Name
 KLKB1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
14VAGYRVLKGTEAVIIubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Heme; Hydrolase; Iron; Metal-binding; Monooxygenase; Oxidoreductase; Protease; Reference proteome; Serine protease. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 686 AA 
Protein Sequence
XSEDCEVAGY RVLKGTEAVI IPYALHRDPR YFPNPEEFQP ERFFPENAQG RHPYAYVPFS 60
AGPRNCIGCL TQLYENAFFR GGDVASMYTP NAQYCQMRCT FHPRCLLFSF LPASSINDME 120
KRFGCFLKDS VTGTLPKVHR TGAVSGHSLK QCGHQISACH RDIYKGVDMR GVNFNVSKVS 180
SVEECQKRCT SNIRCQFFSY ATQTFHKAEY RNNCLLKYSP GGTPTAIKVL SNVESGFSLK 240
PCALSEIGCH MNIFQHLAFS DVDVARVLTP DAFVCRTICT YHPNCLFFTF YTNVWKIESQ 300
RNVCLLKTSE SGTPSSSTPQ ENTISGYSLL TCKRTLPEPC HSKIYPGVDF GGEELNVTFV 360
KGVNVCQETC TKMIRCQFFT YSLLPEDCKE EKCKCFLRLS MDGSPTRIAY GTQGSSGYSL 420
RLCNTGDNSV CTTKTSTRIV GGTNSSWGEW PWQVSLQVKL TAQRHLCGGS LIGHQWVLTA 480
AHCFDGLPLQ DVWRIYSGIL NLSDITKDTP FSQIKEIIIH QNYKVSEGNH DIALIKLQAP 540
LNYTEFQKPI CLPSKGDTST IYTNCWVTGW GFSKEKGEIQ NILQKVNIPL VTNEECQKRY 600
QDYKITQRMV CAGYKEGGKD ACKGDSGGPL VCKHNGMWRL VGITSWGEGC ARREQPGVYT 660
KVAEYMDWIL EKTQSSDGKA QMQSPA 686 
Gene Ontology
 GO:0005576; C:extracellular region; IEA:InterPro.
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0020037; F:heme binding; IEA:InterPro.
 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
 GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
 GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
 GO:0007596; P:blood coagulation; IEA:InterPro.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW. 
Interpro
 IPR000177; Apple.
 IPR001128; Cyt_P450.
 IPR017972; Cyt_P450_CS.
 IPR003014; PAN-1_domain.
 IPR003609; Pan_app.
 IPR001254; Peptidase_S1.
 IPR018114; Peptidase_S1_AS.
 IPR001314; Peptidase_S1A.
 IPR009003; Trypsin-like_Pept_dom. 
Pfam
 PF00067; p450
 PF00024; PAN_1
 PF00089; Trypsin 
SMART
 SM00223; APPLE
 SM00020; Tryp_SPc 
PROSITE
 PS00495; APPLE
 PS00086; CYTOCHROME_P450
 PS50948; PAN
 PS50240; TRYPSIN_DOM
 PS00134; TRYPSIN_HIS
 PS00135; TRYPSIN_SER 
PRINTS
 PR00005; APPLEDOMAIN.
 PR00722; CHYMOTRYPSIN.