UniProt Accession

 MUG_ECOLI; P0A9H1; P43342; Q2M9D7 

Genbank Protein ID

 U28379; U00096; AP009048; J01687 

Genbank Nucleotide ID

 AAA89148.1; AAC76104.1; BAE77119.1 

Protein Name

 G/U mismatch-specific DNA glycosylase 

Protein Synonyms/Alias

 Double-strand-specific uracil glycosylase; Mismatch-specific uracil DNA-glycosylase; MUG 

Gene Name

 mug 

Gene Synonyms/Alias

 ygjF; b3068; JW3040 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
52	GFTDRQLKPQEAQHL	acetylation	[1]
68	DYRCGVTKLVDRPTV	acetylation	[1]
82	VQANEVSKQELHAGG	acetylation	[1]
95	GGRKLIEKIEDYQPQ	acetylation	[1]
109	QALAILGKQAYEQGF	acetylation	[1]
151	LSRVSLEKLVEAYRE	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Excises ethenocytosine and uracil, which can arise by alkylation or deamination of cytosine, respectively, from the corresponding mispairs with guanine in ds-DNA. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and the mispaired base. The complementary strand guanine functions in substrate recognition. Required for DNA damage lesion repair in stationary-phase cells. 

Sequence Annotation

  

Keyword

 3D-structure; Complete proteome; Cytoplasm; DNA damage; DNA excision; DNA repair; DNA-binding; Glycosidase; Hydrolase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 168 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0008263; F:pyrimidine-specific mismatch base pair DNA N-glycosylase activity; IDA:EcoCyc.
 GO:0006285; P:base-excision repair, AP site formation; IDA:EcoCyc. 

Interpro

 IPR023502; DNA_glyclase_G/T-mismatch_bac.
 IPR015637; DNA_glycosylase_G/T-mismatch.
 IPR005122; Uracil-DNA_glycosylase-like. 

Pfam

 PF03167; UDG 

SMART

 SM00986; UDG 

PROSITE

  

PRINTS