CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007621
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 NADH dehydrogenase 
Protein Synonyms/Alias
 Alkyl hydroperoxide reductase 
Gene Name
 ahpF 
Gene Synonyms/Alias
 ndh; BSU40100 
Created Date
 July 27, 2013 
Organism
 Bacillus subtilis (strain 168) 
NCBI Taxa ID
 224308 
Lysine Modification
Position
Peptide
Type
References
106RPPKVDQKVIDQVKKacetylation[1]
274ASLEEHVKEYDIDVMacetylation[1]
292RAKRLEKKDLFELELacetylation[1]
Reference
 [1] The acetylproteome of Gram-positive model bacterium Bacillus subtilis.
 Kim D, Yu BJ, Kim JA, Lee YJ, Choi SG, Kang S, Pan JG.
 Proteomics. 2013 May;13(10-11):1726-36. [PMID: 23468065
Functional Description
 Transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). 
Sequence Annotation
 NP_BIND 210 241 FAD (By similarity).
 NP_BIND 349 379 NAD (By similarity).
 NP_BIND 469 479 FAD (By similarity).
 REGION 1 ?183 Membrane-binding.
 REGION ?184 509 Catalytic.
 DISULFID 337 340 Redox-active (By similarity).  
Keyword
 Cell membrane; Complete proteome; Direct protein sequencing; Disulfide bond; Electron transport; FAD; Flavoprotein; Membrane; NAD; Oxidoreductase; Redox-active center; Reference proteome; Transport; Ubiquinone. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 509 AA 
Protein Sequence
MVLDANIKAQ LNQYMQLIEN DIVLKVSAGE DDTSKDMLAL VDELASMSSK ISVEKAELNR 60
TPSFSVNRVG EDTGVTFAGI PLGHEFTSLV LALLQVSGRP PKVDQKVIDQ VKKISGEYHF 120
ESYISLTCHN CPDVVQALNM MSVLNPNITH TMIDGAAYKA EVESKNIMAV PTVYLNGESF 180
GSGRMTLEEI LAKMGSGTDA SEFADKEPFD VLVVGGGPAG ASAAIYTARK GIRTGVVAER 240
FGGQVLDTMS IENFISVKAT EGPKLAASLE EHVKEYDIDV MNLQRAKRLE KKDLFELELE 300
NGAVLKSKTV ILSTGARWRN VNVPGEQEFK NKGVAYCPHC DGPLFEGKDV AVIGGGNSGI 360
EAAIDLAGIV NHVTVLEFAP ELKADEVLQK RLYSLPNVTV VKNAQTKEIT GDQSVNGITY 420
VDRETGEEKH VELQGVFVQI GLVPNTEWLE GTVERNRMGE IIVDKHGATS VPGLFAAGDC 480
TDSAYNQIII SMGSGATAAL GAFDYLIRN 509 
Gene Ontology
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0008785; F:alkyl hydroperoxide reductase activity; IEA:InterPro.
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
 GO:0051287; F:NAD binding; IEA:InterPro.
 GO:0003954; F:NADH dehydrogenase activity; IEA:EC.
 GO:0015035; F:protein disulfide oxidoreductase activity; IEA:InterPro.
 GO:0045454; P:cell redox homeostasis; IEA:InterPro.
 GO:0022900; P:electron transport chain; IEA:UniProtKB-KW.
 GO:0000302; P:response to reactive oxygen species; IEA:InterPro. 
Interpro
 IPR012081; Alkyl_hydroperoxide_Rdtase_suF.
 IPR013027; FAD_pyr_nucl-diS_OxRdtase.
 IPR002109; Glutaredoxin.
 IPR008255; Pyr_nucl-diS_OxRdtase_2_AS.
 IPR023753; Pyr_nucl-diS_OxRdtase_FAD/NAD.
 IPR001327; Pyr_OxRdtase_NAD-bd_dom.
 IPR000103; Pyridine_nuc-diS_OxRdtase_2.
 IPR012336; Thioredoxin-like_fold. 
Pfam
 PF00070; Pyr_redox
 PF07992; Pyr_redox_2
 PF13192; Thioredoxin_3 
SMART
  
PROSITE
 PS51354; GLUTAREDOXIN_2
 PS00573; PYRIDINE_REDOX_2 
PRINTS
 PR00368; FADPNR.
 PR00469; PNDRDTASEII.