CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024169
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zinc finger protein 292 
Protein Synonyms/Alias
 Zinc finger protein 15; Zfp-15 
Gene Name
 Zfp292 
Gene Synonyms/Alias
 Zfp15 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
1104NSSQSIGKHMKTAHPacetylation[1, 2]
2020NATVIPEKQLAEKKSacetylation[2, 3]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 
Functional Description
 May be involved in transcriptional regulation. 
Sequence Annotation
 ZN_FING 567 589 C2H2-type 1.
 ZN_FING 681 705 C2H2-type 2.
 ZN_FING 722 744 C2H2-type 3.
 ZN_FING 750 774 C2H2-type 4.
 ZN_FING 779 803 C2H2-type 5.
 ZN_FING 807 831 C2H2-type 6.
 ZN_FING 1085 1110 C2H2-type 7.
 ZN_FING 1361 1383 C2H2-type 8; degenerate.
 ZN_FING 1879 1904 C2H2-type 9.
 ZN_FING 1924 1949 C2H2-type 10.
 ZN_FING 2091 2116 C2H2-type 11.
 ZN_FING 2149 2174 C2H2-type 12.
 ZN_FING 2193 2218 C2H2-type 13.
 ZN_FING 2233 2258 C2H2-type 14.
 ZN_FING 2362 2386 C2H2-type 15.
 MOD_RES 1146 1146 Phosphoserine (By similarity).  
Keyword
 Alternative splicing; Complete proteome; DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2698 AA 
Protein Sequence
MADDEAEQER LSGGGCAAEL RRLGERLQEL ERRLCESREP AVEAAAAYCR QLCQTLLEYA 60
EKWKTSEDPL PLLEVYTVAI QSYVKARPYL TSECESVALV LERLALSCVE LLLCLPVELS 120
DKQWEQFQTL VQVAHETLME SGSCELQFLA TLAQETGVWK NAVLSTILSQ EPLDKEKVNE 180
FLAFEGPILL DMRIKHLIKT NQLSQATALA KLCSDHPEIG TKGSFKQTYL VCLCTSSPSE 240
KLIEEISEVD CKDALEMICN LESEGDEKSA LVLCTAFLSR QLQQGDMYCA WELTLFWSKL 300
QQRVEPSVQV YLERCRQLSL LTKTVYHIFF LIKVINSETE GAGLATCIEL CVKALRLEST 360
ENTEVKISIC KTISCLLPED LEVKRACQLS EFLIEPTVDA YYAVEMLYNQ PDQKYDEENL 420
PIPNSLRCEL LLVLKTQWPF DPEFWDWKTL KRQCLALMGE EASIVSSIDE LNDSEVYEKV 480
DYQGERGDTS VNGLSAAGLG TDSGLLMDTG DEKQKKKEIK ELKDRGFISA RFRNWQAYMQ 540
YCLLCDKEFL GHRIVRHAQK HYKDGIYSCP ICAKNFNSKD SFVPHVTLHV KQSSKERLAA 600
MKPLRRLGRP PKITATHENQ KTNINTVAKQ EQRPIKKNSL YSTDFIVFND NDGSDDENDD 660
KDKSYEPEVI PVQKPVPVNE FNCPVTFCKK GFKYFKNLIA HVKGHKDSED AKRFLEMQSK 720
KVICQYCRRH FVSVTHLNDH LQMHCGSKPY ICIQMKCKAG FNSYAELLAH RKEHQVFRAK 780
CLFPKCGRIF SQAYLLYDHE AQHYNTYTCK FTGCGKVYRS QSEMEKHQDG HSHPETGLPP 840
EDQLQPSGND VNPDSGATAA GGRSENSIDK NLGSNRSADW EKNRAEPAVT KHGQISAAEL 900
RQANIPLSNG LETRDNTTVL RTNEVAVSIK VSVNHGVEGD FGKQENLTME GTGEPLITDV 960
HKPGIGAGVQ LCHPGFQEKK GHECLNEAQN SLSNSESLKM DDLNPQSLER QVNTLMTFSV 1020
QNEAGLEDNS QICKFECGGD VKTSSSLYDL PLKTLESITF VQSQPDLSSP LGSPSVPPKA 1080
PGQKFSCQVE GCTRTYNSSQ SIGKHMKTAH PDQYAAFKLQ RKTKKGQKSN NLNTPNHGKC 1140
VYFLPSQVSS SNHAFFTPQT KANGNPACSA QVQHVSPSIF PAHLASVSAP LLPSVESVLS 1200
PNIPSQDKHG QDGILCSQME NLSNAPLPAQ MEDLTKTVLP LNIDSGSDPF LPLPTENSSL 1260
FSSPADSENN SVFSQLENST NHYPSQTDGN INSSFLKGGS SENGVFPSQV SSADDFSSTS 1320
AQPSTPKKVK KDRGRGPNGK ERKPKHNKRA KWPAIIRDGK FICSRCYRAF TNPRSLGGHL 1380
SKRSYCKPLD GAEIAQELLQ TNRQPSLLAS MILSTSAVNM QQPQQSNFNP ETCFKDPSFL 1440
QLLNVENRPT FLPSTFPRCD VSNFNASVSQ EGSEIIKQAL ETAGIPSTFE SAEMLSQVVP 1500
IGSVSDAAQV SAAGMPGPPV TPLLQTVCHP NTSPSNQNQT PNSKTLKECN SLPLFTTNDL 1560
LLKTIENGLC SNSFSSSTEP PQNFTNNSAH VSVISGPQNT RSSHLNKKGN SASKKRKKVA 1620
PAVSVSNTSQ NVLPTDLPVG LPAKNLPVPD TNTRSDMTPD CEPRALVENL TQKLNNIDNH 1680
LFITDVKENC KASLEPHTML TPLTLKTENG DSRMMPLSSC TPVNSDLQIS EDNVIQNFEK 1740
TLEIIKTAMN SQILEVKSGS QGTGETTQNA QINYSMQLPS VNSIPDNKLP DASQCSSFLT 1800
VMPTKSEALH KEDQIQDILE GLQNLKLEND TSAPASQSML MNKSVALSPT PTKSTPNIVV 1860
QPVPEVIHVQ LNDRVNKPFV CQNQGCNYSA MTKDALFKHY GKIHQYTPEM ILEIKKNQLK 1920
FAPFKCVVPS CTKTFTRNSN LRAHCQLVHH FTIEEMVKLK IKRPYGRKSQ SENLSSPQNN 1980
QVKKQPSMAE ETKTESQPAF KVPAATGDAA LANATVIPEK QLAEKKSPEK PESSSQPVTS 2040
SAEQYNANLA NLKTKGRKNK RHRKEKEEKR EKNPVSQAFE LPTKYSSYRP YCCVHQGCFA 2100
AFTIQQNLIL HYQAVHKSNL PTFSAEVEEE SEAVKESEET EPKQSMKEFR CQVSDCSRIF 2160
QAITGLIQHY MKLHEMTPEE IESMTAAVDV GKFPCDQLEC KLSFTTYLSY VVHLEVDHGI 2220
GTRTSKAEED GIYKCDCEGC DRIYATRSNL LRHIFNKHND KHKAHLIRPR KLTGQENISS 2280
KANQEKSKSK HRTTKPNRSG KDGMKMPKTK RKKKSNLENK SAKVVQIEEN KPYSLKRGKH 2340
VYSIKARNDA LAECTSKFVT QYPCMIKGCT SVVTSESNII RHYKCHKLSR AFTSQHRNIL 2400
IVFKRYGNPQ GKEISEQEDE KNDKKDPDSS VLEKNDNSEP AAAPQEEGRK GEKDEMDELT 2460
ELFITKLINE DSTNAENQGN TTLKGNNEFQ EHDSCTSERQ KPGNLKRVYK EKNTVQSKKR 2520
KIDKTEPEVS LVVNNTRKEE EPAVAVQTTE EHPASFDWSS FKPMGFEASF LKFLEESAVK 2580
QKKNSDRDHS NSGSKRGSHS SSRRHVDKAA VAGSSHVCSC KDSEIFVQFA NPSKLQCSEN 2640
VKIVLDKTLK DRSELVLKQL QEMKPTVSLK KLEVLSNNPD RTVLKEISIG KATGRGQY 2698 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0001077; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; IEA:Compara.
 GO:0008270; F:zinc ion binding; IEA:InterPro. 
Interpro
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
 PF00096; zf-C2H2 
SMART
 SM00355; ZnF_C2H2 
PROSITE
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS