UniProt Accession

 PCBP2_MOUSE; Q61990; Q61383; Q62042 

Genbank Protein ID

 L19661; X75947; X97982; AF236845; AF236842; AF236843; AF236844 

Genbank Nucleotide ID

 AAA03705.1; CAA53546.1; CAA66619.1; AAK14059.1; AAK14059.1; AAK14059.1; AAK14059.1 

Protein Name

 Poly(rC)-binding protein 2 

Protein Synonyms/Alias

 Alpha-CP2; CTBP; CBP; Putative heterogeneous nuclear ribonucleoprotein X; hnRNP X 

Gene Name

 Pcbp2 

Gene Synonyms/Alias

 Cbp; Hnrnpx; Hnrpx 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
115	QCGSLIGKGGCKIKE	acetylation	[1]
115	QCGSLIGKGGCKIKE	ubiquitination	[2]
181	VTIPYRPKPSSSPVI	acetylation	[3]
181	VTIPYRPKPSSSPVI	ubiquitination	[2]
319	QMSGAQIKIANPVEG	ubiquitination	[2]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. Major cellular poly(rC)-binding protein. Binds also poly(rU). Negatively regulates cellular antiviral responses mediated by MAVS signaling. It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitinationa and degradation (By similarity). 

Sequence Annotation

 DOMAIN 13 75 KH 1.
 DOMAIN 97 162 KH 2.
 DOMAIN 284 348 KH 3.
 MOD_RES 169 169 Phosphoserine (By similarity).
 MOD_RES 185 185 Phosphoserine (By similarity).
 MOD_RES 268 268 Phosphoserine (By similarity).
 MOD_RES 361 361 Phosphoserine (By similarity).  

Keyword

 Alternative splicing; Antiviral defense; Complete proteome; Cytoplasm; Direct protein sequencing; DNA-binding; Immunity; Innate immunity; Nucleus; Phosphoprotein; Reference proteome; Repeat; Ribonucleoprotein; RNA-binding. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 362 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0030529; C:ribonucleoprotein complex; IEA:UniProtKB-KW.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
 GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
 GO:0050687; P:negative regulation of defense response to virus; ISS:UniProtKB.
 GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; ISS:UniProtKB. 

Interpro

 IPR004087; KH_dom.
 IPR004088; KH_dom_type_1. 

Pfam

 PF00013; KH_1 

SMART

 SM00322; KH 

PROSITE

 PS50084; KH_TYPE_1 

PRINTS