| Tag | Content |
|---|
| CPLM ID | CPLM-014302 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | NGFI-A-binding protein 1 |
Protein Synonyms/Alias | EGR-1-binding protein 1 |
Gene Name | Nab1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 354 | LFQQARAKSEELAGL | ubiquitination | [1] | | 368 | LGSQQAEKGMAKQME | ubiquitination | [1] | | 372 | QAEKGMAKQMELLCA | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2 (By similarity). |
Sequence Annotation | REGION 4 82 NCD1.
REGION 220 309 NCD2.
REGION 306 337 Necessary for nuclear localization (By
MOD_RES 327 327 Phosphoserine (By similarity).
MOD_RES 401 401 Phosphoserine.
CROSSLNK 332 332 Glycyl lysine isopeptide (Lys-Gly)
CROSSLNK 479 479 Glycyl lysine isopeptide (Lys-Gly) |
Keyword | Complete proteome; Isopeptide bond; Nucleus; Phosphoprotein; Reference proteome; Repressor; Transcription; Transcription regulation; Ubl conjugation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 486 AA |
Protein Sequence | MATALPRTLG ELQLYRILQK ANLLSYFDAF IQQGGDDVQQ LCEAGEEEFL EIMALVGMAS 60
KPLHVRRLQK ALRDWVTNPG LFNQPLTSLP VSSIPIYKLP EGSPTWLGIS CNSYERSSSS 120
REPHLKIPKC AATTCVQSLG QGKSEVGSLA LQSVSDSRLW QGHHATESEH SLSPADLGSP 180
ASPKESSEAL DAAAALSVAE CVERMAPTLP KSDLSEVKEL LKNNKKLAKM IGHIFEMSDE 240
DPHKEEEIRK YSAIYGRFDS KRKDGKHLTL HELTVNEAAA QLCVKDNALL TRRDELFALA 300
RQVSREVTYK YTYRTTRLKC GERDELSPKR IKIEDGFPDF QESVPTLFQQ ARAKSEELAG 360
LGSQQAEKGM AKQMELLCAQ AGYERLQQER RLTAGLYRQS SGEQSPDGGL PSDSSDGQGE 420
RPLNLRIPSV QNRQPHHFVV DGELSRLYSS EAKSHSSESL GILKDYPHSA FTLEKKVIKT 480
EPEDSR 486 |
Gene Ontology | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0008134; F:transcription factor binding; IDA:MGI. GO:0001958; P:endochondral ossification; IGI:MGI. GO:0042552; P:myelination; IGI:MGI. GO:0045892; P:negative regulation of transcription, DNA-dependent; IEA:InterPro. GO:0045682; P:regulation of epidermis development; IGI:MGI. GO:0006355; P:regulation of transcription, DNA-dependent; IGI:MGI. GO:0014037; P:Schwann cell differentiation; IGI:MGI. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |