CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037611
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 60S ribosomal protein L27a 
Protein Synonyms/Alias
  
Gene Name
 RPL27A 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
20CPTVNLDKLWTLVSEubiquitination[1, 2]
35QTRVNAAKNKTGAAPubiquitination[3, 4]
37RVNAAKNKTGAAPIIubiquitination[2, 3, 4, 5]
53VVRSGYYKVLGKGKLacetylation[6]
53VVRSGYYKVLGKGKLubiquitination[2, 5, 7]
57GYYKVLGKGKLPKQPubiquitination[2]
59YKVLGKGKLPKQPVIubiquitination[2]
68PKQPVIVKAKFFSRRubiquitination[2, 4, 5, 7]
81RRAEEKIKSVGGACVubiquitination[5]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [6] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [7] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; Ribonucleoprotein; Ribosomal protein. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 91 AA 
Protein Sequence
MKHYHLKRNQ SFCPTVNLDK LWTLVSEQTR VNAAKNKTGA APIIDVVRSG YYKVLGKGKL 60
PKQPVIVKAK FFSRRAEEKI KSVGGACVLV A 91 
Gene Ontology
 GO:0005840; C:ribosome; IEA:UniProtKB-KW.
 GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
 GO:0006412; P:translation; IEA:InterPro. 
Interpro
 IPR001196; Ribosomal_L15_CS.
 IPR021131; Ribosomal_L18e/L15P. 
Pfam
 PF00828; Ribosomal_L18e 
SMART
  
PROSITE
 PS00475; RIBOSOMAL_L15 
PRINTS