| Tag | Content |
|---|
| CPLM ID | CPLM-010911 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | A-kinase anchor protein 17A |
Protein Synonyms/Alias | AKAP-17A; 721P; B-lymphocyte antigen; Protein XE7; Protein kinase A-anchoring protein 17A; PRKA17A; Splicing factor, arginine/serine-rich 17A |
Gene Name | AKAP17A |
Gene Synonyms/Alias | CXYorf3; DXYS155E; SFRS17A; XE7 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 180 | VLVKVFEKFGEIRNV | ubiquitination | [1] |
|
Reference | [1] Integrated proteomic analysis of post-translational modifications by serial enrichment. Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA. Nat Methods. 2013 Jul;10(7):634-7. [ PMID: 23749302] |
Functional Description | Splice factor regulating alternative splice site selection for certain mRNA precursors. Mediates regulation of pre- mRNA splicing in a PKA-dependent manner. |
Sequence Annotation | DOMAIN 147 256 RRM.
REGION 83 112 PKA-RI and PKA-RII subunit binding
REGION 425 454 PKA-RI-alpha subunit binding domain.
MOD_RES 537 537 Phosphoserine.
MOD_RES 633 633 Phosphoserine. |
Keyword | Alternative splicing; Complete proteome; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; RNA-binding; Spliceosome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 695 AA |
Protein Sequence | MAAATIVHDT SEAVELCPAY GLYLKPITKM TISVALPQLK QPGKSISNWE VMERLKGMVQ 60
NHQFSTLRIS KSTMDFIRFE GEVENKSLVK SFLACLDGKT IKLSGFSDIL KVRAAEFKID 120
FPTRHDWDSF FRDAKDMNET LPGERPDTIH LEGLPCKWFA LKESGSEKPS EDVLVKVFEK 180
FGEIRNVDIP MLDPYREEMT GRNFHTFSFG GHLNFEAYVQ YREYMGFIQA MSALRGMKLM 240
YKGEDGKAVA CNIKVSFDST KHLSDASIKK RQLERQKLQE LEQQREEQKR REKEAEERQR 300
AEERKQKELE ELERERKREE KLRKREQKQR DRELRRNQKK LEKLQAEEQK QLQEKIKLEE 360
RKLLLAQRNL QSIRLIAELL SRAKAVKLRE QEQKEEKLRL QQQEERRRLQ EAELRRVEEE 420
KERALGLQRK ERELRERLLS ILLSKKPDDS HTHDELGVAH ADLLQPVLDI LQTVSSGCVS 480
ATTLHPLGGQ PPAGAPKESP AHPEADGAPK SVNGSVAEEA PCKEVQSSCR VVPEDGSPEK 540
RCPGGVLSCI PDNNQQPKGI PACEQNVSRK DTRSEQDKCN REPSKGRGRA TGDGLADRHK 600
RERSRARRAS SREDGRPRKE RRPHKKHAYK DDSPRRRSTS PDHTRSRRSH SKDRHRRERS 660
RERRGSASRK HSRHRRRSER SRSRSPSRHR STWNR 695 |
Gene Ontology | GO:0016607; C:nuclear speck; IDA:UniProtKB. GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW. GO:0000166; F:nucleotide binding; IEA:InterPro. GO:0051018; F:protein kinase A binding; IDA:UniProtKB. GO:0003723; F:RNA binding; IEA:UniProtKB-KW. GO:0042113; P:B cell activation; NAS:UniProtKB. GO:0006397; P:mRNA processing; IEA:UniProtKB-KW. GO:0043484; P:regulation of RNA splicing; IMP:UniProtKB. GO:0006355; P:regulation of transcription, DNA-dependent; NAS:UniProtKB. GO:0008380; P:RNA splicing; IEA:UniProtKB-KW. GO:0007165; P:signal transduction; NAS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |