UniProt Accession

 CSRP1_MOUSE; P97315 

Genbank Protein ID

 D88793; AF092921; AK077787; AK087436; BC006912 

Genbank Nucleotide ID

 BAA13723.1; AAD19352.1; BAC37009.1; BAC39873.1; AAH06912.1 

Protein Name

 Cysteine and glycine-rich protein 1 

Protein Synonyms/Alias

 Cysteine-rich protein 1; CRP; CRP1 

Gene Name

 Csrp1 

Gene Synonyms/Alias

 Crp1; Csrp 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
59	HGEEIYCKSCYGKKY	acetylation	[1]
84	AGTLSTDKGESLGIK	acetylation	[2, 3]
108	TTNPNASKFAQKIGG	acetylation	[3]
112	NASKFAQKIGGSERC	acetylation	[3]
112	NASKFAQKIGGSERC	ubiquitination	[4]
131	QAVYAAEKVIGAGKS	acetylation	[3]
137	EKVIGAGKSWHKSCF	acetylation	[3]
161	ESTTLADKDGEIYCK	acetylation	[2, 3, 5]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [4] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [5] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758] 

Functional Description

 Could play a role in neuronal development (By similarity). 

Sequence Annotation

 DOMAIN 10 61 LIM zinc-binding 1.
 DOMAIN 119 170 LIM zinc-binding 2.
 MOTIF 64 69 Nuclear localization signal (Potential).
 MOD_RES 112 112 N6-acetyllysine (By similarity).
 MOD_RES 127 127 Phosphotyrosine.
 MOD_RES 131 131 N6-acetyllysine (By similarity).
 MOD_RES 192 192 Phosphoserine.  

Keyword

 Acetylation; Complete proteome; Direct protein sequencing; LIM domain; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 193 AA 

Protein Sequence

Gene Ontology

 GO:0015629; C:actin cytoskeleton; TAS:MGI.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0030036; P:actin cytoskeleton organization; TAS:MGI. 

Interpro

 IPR001781; Znf_LIM. 

Pfam

 PF00412; LIM 

SMART

 SM00132; LIM 

PROSITE

 PS00478; LIM_DOMAIN_1
 PS50023; LIM_DOMAIN_2 

PRINTS