CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041678
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Myosin-6 
Protein Synonyms/Alias
 RCG23609, isoform CRA_a 
Gene Name
 Myh6 
Gene Synonyms/Alias
 rCG_23609 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
58IVSREGGKVTAETENacetylation[1]
67TAETENGKTVTVKEDacetylation[1]
279SRVIFQLKAERNYHIacetylation[1]
364IMHYGNMKFKQKQREacetylation[1]
550KATDMTFKAKLYDNHacetylation[1]
560LYDNHLGKSNNFQKPacetylation[1]
566GKSNNFQKPRNVKGKacetylation[1]
742GQFIDSRKGAEKLLGacetylation[1]
746DSRKGAEKLLGSLDIacetylation[1]
759DIDHNQYKFGHTKVFacetylation[1]
768GHTKVFFKAGLLGLLacetylation[1]
849LKSAETEKEMANMKEacetylation[1]
855EKEMANMKEEFGRVKacetylation[1]
862KEEFGRVKDALEKSEacetylation[1]
867RVKDALEKSEARRKEacetylation[1]
941MNAELTAKKRKLEDEacetylation[1]
993GLDEIIAKLTKEKKAacetylation[1]
1018DLQAEEDKVNTLIKSacetylation[1]
1028TLIKSKVKLEQQVDDacetylation[1]
1075IMDLENDKLQLEEKLacetylation[1]
1085LEEKLKKKEFDISQQacetylation[1]
1108ALALQLQKKLKENQAacetylation[1]
1242SNMEQIIKAKANLEKacetylation[1]
1249KAKANLEKVSRTLEDacetylation[1]
1281DFTTQRAKLQTENGEacetylation[1]
1296LARQLEEKEALISQLacetylation[1]
1307ISQLTRGKLSYTQQMacetylation[1]
1318TQQMEDLKRQLEEEGacetylation[1]
1326RQLEEEGKAKNALAHacetylation[1]
1356YEEEMEAKAELQRVLacetylation[1]
1446AAAAALDKKQRNFDKacetylation[1]
1461ILAEWKQKYEESQSEacetylation[1]
1474SELESSQKEARSLSTacetylation[1]
1501LEHLETFKRENKNLQacetylation[1]
1505ETFKRENKNLQEEISacetylation[1]
1530KNVHELEKIRKQLEVacetylation[1]
1539RKQLEVEKLELQSALacetylation[1]
1559SLEHEEGKILRAQLEacetylation[1]
1571QLEFNQIKAEIERKLacetylation[1]
1581IERKLAEKDEEMEQAacetylation[1]
1589DEEMEQAKRNHLRVVacetylation[1]
1643RIASEAQKHLKNAQAacetylation[1]
1653KNAQAHLKDTQLQLDacetylation[1]
1702EQTERSRKLAEQELIacetylation[1]
1729NTSLINQKKKMDADLacetylation[1]
1793KNMEQTIKDLQHRLDacetylation[1]
1833NELEAEQKRNAESVKacetylation[1]
1840KRNAESVKGMRKSERacetylation[1]
1850RKSERRIKELTYQTEacetylation[1]
1860TYQTEEDKKNLVRLQacetylation[1]
1861YQTEEDKKNLVRLQDacetylation[1]
1872RLQDLVDKLQLKVKAacetylation[1]
1876LVDKLQLKVKAYKRQacetylation[1]
1897QANTNLSKFRKVQHEacetylation[1]
1900TNLSKFRKVQHELDEacetylation[1]
1921IAESQVNKLRAKSRDacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Actin-binding; ATP-binding; Coiled coil; Complete proteome; Motor protein; Myosin; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1939 AA 
Protein Sequence
MTDAQMADFG AAAPYLRKSE KERLEAQTRP FDIRTECFVP DDKEEYVKAK IVSREGGKVT 60
AETENGKTVT VKEDQVMQQN PPKFDKIEDM AMLTFLHEPA VLYNLKERYA AWMIYTYSGL 120
FCVTVNPYKW LPVYNAEVVA AYRGKKRSEA PPHIFSISDN AYQYMLTDRE NQSILITGES 180
GAGKTVNTKR VIQYFASIAA IGDRSKKDNP NANKGTLEDQ IIQANPALEA FGNAKTVRND 240
NSSRFGKFIR IHFGATGKLA SADIETYLLE KSRVIFQLKA ERNYHIFYQI LSNKKPELLD 300
MLLVTNNPYD YAFVSQGEVS VASIDDSEEL LATDSAFDVL GFTAEEKAGV YKLTGAIMHY 360
GNMKFKQKQR EEQAEPDGTE DADKSAYLMG LNSADLLKGL CHPRVKVGNE YVTKGQSVQQ 420
VYYSIGALAK SVYEKMFNWM VTRINATLET KQPRQYFIGV LDIAGFEIFD FNSFEQLCIN 480
FTNEKLQQFF NHHMFVLEQE EYKKEGIEWE FIDFGMDLQA CIDLIEKPMG IMSILEEECM 540
FPKATDMTFK AKLYDNHLGK SNNFQKPRNV KGKQEAHFSL VHYAGTVDYN ILGWLEKNKD 600
PLNETVVGLY QKSSLKLMAT LFSTYASADT GDSGKGKGGK KKGSSFQTVS ALHRENLNKL 660
MTNLRTTHPH FVRCIIPNER KAPGVMDNPL VMHQLRCNGV LEGIRICRKG FPNRILYGDF 720
RQRYRILNPA AIPEGQFIDS RKGAEKLLGS LDIDHNQYKF GHTKVFFKAG LLGLLEEMRD 780
ERLSRIITRI QAQARGQLMR IEFKKMVERR DALLVIQWNI RAFMGVKNWP WMKLYFKIKP 840
LLKSAETEKE MANMKEEFGR VKDALEKSEA RRKELEEKMV SLLQEKNDLQ LQVQAEQDNL 900
ADAEERCDQL IKNKIQLEAK VKEMTERLED EEEMNAELTA KKRKLEDECS ELKKDIDDLE 960
LTLAKVEKEK HATENKVKNL TEEMAGLDEI IAKLTKEKKA LQEAHQQALD DLQAEEDKVN 1020
TLIKSKVKLE QQVDDLEGSL EQEKKVRMDL ERAKRKLEGD LKLTQESIMD LENDKLQLEE 1080
KLKKKEFDIS QQNSKIEDEQ ALALQLQKKL KENQARIEEL EEELEAERTA RAKVEKLRSD 1140
LTRELEEISE RLEEAGGATS VQIEMNKKRE AEFQKMRRDL EEATLQHEAT AAALRKKHAD 1200
SVAELGEQID NLQRVKQKLE KEKSEFKLEL DDVTSNMEQI IKAKANLEKV SRTLEDQANE 1260
YRVKLEEAQR SLNDFTTQRA KLQTENGELA RQLEEKEALI SQLTRGKLSY TQQMEDLKRQ 1320
LEEEGKAKNA LAHALQSARH DCDLLREQYE EEMEAKAELQ RVLSKANSEV AQWRTKYETD 1380
AIQRTEELEE AKKKLAQRLQ DAEEAVEAVN AKCSSLEKTK HRLQNEIEDL MVDVERSNAA 1440
AAALDKKQRN FDKILAEWKQ KYEESQSELE SSQKEARSLS TELFKLKNAY EESLEHLETF 1500
KRENKNLQEE ISDLTEQLGE GGKNVHELEK IRKQLEVEKL ELQSALEEAE ASLEHEEGKI 1560
LRAQLEFNQI KAEIERKLAE KDEEMEQAKR NHLRVVDSLQ TSLDAETRSR NEALRVKKKM 1620
EGDLNEMEIQ LSQANRIASE AQKHLKNAQA HLKDTQLQLD DAVRANDDLK ENIAIVERRN 1680
TLLQAELEEL RAVVEQTERS RKLAEQELIE TSERVQLLHS QNTSLINQKK KMDADLSQLQ 1740
TEVEEAVQEC RNAEEKAKKA ITDAAMMAEE LKKEQDTSAH LERMKKNMEQ TIKDLQHRLD 1800
EAEQIALKGG KKQLQKLEAR VRELENELEA EQKRNAESVK GMRKSERRIK ELTYQTEEDK 1860
KNLVRLQDLV DKLQLKVKAY KRQAEEAEEQ ANTNLSKFRK VQHELDEAEE RADIAESQVN 1920
KLRAKSRDIG AKQKMHDEE 1939 
Gene Ontology
 GO:0005925; C:focal adhesion; IEA:Compara.
 GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
 GO:0005730; C:nucleolus; IEA:Compara.
 GO:0001725; C:stress fiber; IEA:Compara.
 GO:0030018; C:Z disc; IEA:Compara.
 GO:0030898; F:actin-dependent ATPase activity; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0000146; F:microfilament motor activity; IEA:Compara.
 GO:0008307; F:structural constituent of muscle; IEA:Compara.
 GO:0007512; P:adult heart development; IEA:Compara.
 GO:0055009; P:atrial cardiac muscle tissue morphogenesis; IEA:Compara.
 GO:0030509; P:BMP signaling pathway; IEA:Compara.
 GO:0060070; P:canonical Wnt receptor signaling pathway; IEA:Compara.
 GO:0048739; P:cardiac muscle fiber development; IEA:Compara.
 GO:0001701; P:in utero embryonic development; IEA:Compara.
 GO:0030049; P:muscle filament sliding; IEA:Compara.
 GO:0043462; P:regulation of ATPase activity; IEA:Compara.
 GO:0008217; P:regulation of blood pressure; IEA:Compara.
 GO:0060420; P:regulation of heart growth; IEA:Compara.
 GO:0002027; P:regulation of heart rate; IEA:Compara.
 GO:0002026; P:regulation of the force of heart contraction; IEA:Compara.
 GO:0045214; P:sarcomere organization; IEA:Compara.
 GO:0006941; P:striated muscle contraction; IEA:Compara.
 GO:0055010; P:ventricular cardiac muscle tissue morphogenesis; IEA:Compara.
 GO:0007522; P:visceral muscle development; IEA:Compara. 
Interpro
 IPR000048; IQ_motif_EF-hand-BS.
 IPR027401; Myosin-like_IQ_dom.
 IPR001609; Myosin_head_motor_dom.
 IPR004009; Myosin_N.
 IPR002928; Myosin_tail.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00063; Myosin_head
 PF02736; Myosin_N
 PF01576; Myosin_tail_1 
SMART
 SM00015; IQ
 SM00242; MYSc 
PROSITE
 PS50096; IQ 
PRINTS
 PR00193; MYOSINHEAVY.