UniProt Accession

 MVD1_MOUSE; Q99JF5; Q3TCD8; Q8BTM4; Q922D7 

Genbank Protein ID

 AJ309922; AK089354; AK154883; AK170773; BC008526 

Genbank Nucleotide ID

 CAC35731.1; BAC40852.1; BAE32901.1; BAE42019.1; AAH08526.1 

Protein Name

 Diphosphomevalonate decarboxylase 

Protein Synonyms/Alias

 Mevalonate (diphospho)decarboxylase; MDDase; Mevalonate pyrophosphate decarboxylase 

Gene Name

 Mvd 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
208	LVVSADKKQTGSTVG	ubiquitination	[1]
339	PPAANGDKFLKGLQV	ubiquitination	[1]
342	ANGDKFLKGLQVAPV	acetylation	[2]
342	ANGDKFLKGLQVAPV	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 Performs the first committed step in the biosynthesis of isoprenes. 

Sequence Annotation

 MOD_RES 2 2 N-acetylalanine (By similarity).  

Keyword

 3D-structure; Acetylation; ATP-binding; Cholesterol biosynthesis; Cholesterol metabolism; Complete proteome; Lipid biosynthesis; Lipid metabolism; Lyase; Nucleotide-binding; Reference proteome; Steroid biosynthesis; Steroid metabolism; Sterol biosynthesis; Sterol metabolism. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 401 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004163; F:diphosphomevalonate decarboxylase activity; IEA:EC.
 GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0008299; P:isoprenoid biosynthetic process; IEA:Compara.
 GO:0008284; P:positive regulation of cell proliferation; IEA:Compara. 

Interpro

 IPR006204; GHMP_kinase_N_dom.
 IPR005935; Mev_diP_decarb.
 IPR020568; Ribosomal_S5_D2-typ_fold.
 IPR014721; Ribosomal_S5_D2-typ_fold_subgr. 

Pfam

 PF00288; GHMP_kinases_N 

SMART

  

PROSITE

  

PRINTS