CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018137
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Fibrinogen gamma chain 
Protein Synonyms/Alias
  
Gene Name
 Fgg 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
83ENRTTEAKELIKAIQubiquitination[1]
100YNPDQPPKPGMIDSAubiquitination[1]
145IYNSNNQKITNLKQKubiquitination[1]
184DCQEIANKGAKESGLubiquitination[1]
231DGSLDFKKNWIQYKEubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation (By similarity). 
Sequence Annotation
 DOMAIN 169 415 Fibrinogen C-terminal.
 CARBOHYD 77 77 N-linked (GlcNAc...) (Potential).
 DISULFID 33 33 Interchain (with gamma chain) (By
 DISULFID 34 34 Interchain (with gamma chain) (By
 DISULFID 44 44 Interchain (with beta chain) (By
 DISULFID 48 48 Interchain (with alpha chain) (By
 DISULFID 160 160 Interchain (with beta chain) (By
 DISULFID 164 164 Interchain (with gamma chain) (By
 DISULFID 178 207 By similarity.
 DISULFID 351 364 By similarity.
 CROSSLNK 423 423 Isoglutamyl lysine isopeptide (Gln-Lys)
 CROSSLNK 431 431 Isoglutamyl lysine isopeptide (Lys-Gln)  
Keyword
 Blood coagulation; Calcium; Coiled coil; Complete proteome; Disulfide bond; Glycoprotein; Hemostasis; Isopeptide bond; Metal-binding; Reference proteome; Secreted; Signal. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 436 AA 
Protein Sequence
MSWSLQPPSF LLCCLLLLFS PTGLAYVATR DNCCILDERF GSFCPTTCGI ADFLSSYQTD 60
VDNDLRTLED ILFRAENRTT EAKELIKAIQ VYYNPDQPPK PGMIDSATQK SKKMVEEIVK 120
YEALLLTHET SIRYLQEIYN SNNQKITNLK QKVAQLEAQC QEPCKDSVQI HDTTGKDCQE 180
IANKGAKESG LYFIRPLKAK QQFLVYCEID GSGNGWTVLQ KRIDGSLDFK KNWIQYKEGF 240
GHLSPTGTTE FWLGNEKIHL ISMQSTIPYA LRIQLKDWNG RTSTADYAMF RVGPESDKYR 300
LTYAYFIGGD AGDAFDGYDF GDDPSDKFFT SHNGMQFSTW DNDNDKFEGN CAEQDGSGWW 360
MNKCHAGHLN GVYHQGGTYS KSSTTNGFDD GIIWATWKSR WYSMKETTMK IIPFNRLSIG 420
EGQQHHMGGS KQAGDV 436 
Gene Ontology
 GO:0072562; C:blood microparticle; IEA:Compara.
 GO:0005938; C:cell cortex; IDA:MGI.
 GO:0009897; C:external side of plasma membrane; IEA:Compara.
 GO:0005577; C:fibrinogen complex; IEA:InterPro.
 GO:0031091; C:platelet alpha granule; IEA:Compara.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0030168; P:platelet activation; IEA:InterPro.
 GO:0051258; P:protein polymerization; IEA:InterPro.
 GO:0051592; P:response to calcium ion; IEA:Compara.
 GO:0007165; P:signal transduction; IEA:InterPro. 
Interpro
 IPR014716; Fibrinogen_a/b/g_C_1.
 IPR014715; Fibrinogen_a/b/g_C_2.
 IPR002181; Fibrinogen_a/b/g_C_dom.
 IPR012290; Fibrinogen_a/b/g_coil_dom.
 IPR020837; Fibrinogen_CS. 
Pfam
 PF08702; Fib_alpha
 PF00147; Fibrinogen_C 
SMART
 SM00186; FBG 
PROSITE
 PS00514; FIBRINOGEN_C_1
 PS51406; FIBRINOGEN_C_2 
PRINTS