CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041340
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Ataxin-3 
Protein Synonyms/Alias
  
Gene Name
 ATXN3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
185RREAYFEKQQQKQQQubiquitination[1, 2, 3, 4, 5, 6]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [5] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [6] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 223 AA 
Protein Sequence
MESIFHEKQP SGNMDDSGFF SIQWFNLNSL LTGPELISDT YLALFLAQLQ QEGYSIFVVK 60
GDLPDCEADQ LLQMIRVQQM HRPKLIGEEL AQLKEQRVHK TDLERVLEAN DGSGMLDEDE 120
EDLQRALALS RQEIDMEDEE ADLRRAIQLS MQGSSRNISQ DMTQTSGTNL TSEELRKRRE 180
AYFEKQQQKQ QQQQQQQQQG DLSGQSSHPC ERPATSSGAL GSD 223 
Gene Ontology
 GO:0008242; F:omega peptidase activity; IEA:InterPro. 
Interpro
 IPR006155; Josephin.
 IPR003903; Ubiquitin-int_motif. 
Pfam
 PF02099; Josephin
 PF02809; UIM 
SMART
 SM00726; UIM 
PROSITE
 PS50957; JOSEPHIN
 PS50330; UIM 
PRINTS
 PR01233; JOSEPHIN.