CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031902
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Kismet, isoform C 
Protein Synonyms/Alias
  
Gene Name
 kis 
Gene Synonyms/Alias
 CG3696; Dmel_CG3696 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
1773VKTEENSKAIEEDKSacetylation[1]
2177RLKNRNCKLLEGLRQacetylation[1]
2570EKGSTFSKASFAASGacetylation[1]
3631LEAFNAEKAEKLAAAacetylation[1]
3878IESEPSEKSETVLEPacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Hydrolase; Nucleus; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 5517 AA 
Protein Sequence
MDGNAQNMFH GNHQGDPYYR YDAAAAAAAA AAANPRAMGP PGGYPPRHRP PHPLQQQPQY 60
PSYQPTAENL YGLGAADHQA AMGLGVGVGV GAGMGDLSGW GAAPSVPGQA AAYPGAGLGA 120
YGHPQAAPPS QQQRQSNASA YRQHMPAYGQ QDQQKLASYG AQQSMMAGYG SLAPQQQQQQ 180
QPPTPQQQQQ AQQVQQQAQQ QQQQQQQQSQ QQARLPQHYP QAPGQHPLYP GVGAPTVQAG 240
QPPTPQAYAH SPYGSPMQHQ PSRGAPQHVG YGHTGLDQAS AYGQHVPGGA PPGHHLSAQQ 300
QQAAQQLGAH QQQQLQSQQQ QQAQQQQPHV SLMQQQQLPG AGLPPPHMGM PPSYGSHHQQ 360
QQQQQQTQQQ QQQSAPPYMS SSKHQQAAAQ LNSSPQYRAP FPQLSPQMSP RPPTMSPHPQ 420
MSPRPVGVSP AKPPPPQQQQ QQTQAQQPQQ VVSNQPSQHS IQGMVGLPSP RPQPPTSGAG 480
GAGAKGPAPV AAPVNTLQAL EQMVMPSQAL GLPPMDYPSA YRSAVGPRMP ASPQQQQQQH 540
QQWGAAHGAQ HLAALQQQQA QQQQQQVQQQ QQAPPQQQQQ AAMLQAQQQH HQQQLSMYGQ 600
PMGQQPQTAQ QQVVPPVTSQ PPVVAASQQQ QQQQHQQQSL NDQLQHSIND IVGGGNSSGA 660
TGGAQNQHQQ QPQLAAMSSP LHQQNLPNMH HLIQPTMETT QPTQQQQQTS QQQQQPQQPQ 720
ATLTSPHHQQ MQHQSPIHQQ QQSPHHQQHL PSYNQSQQQF DPFANILGDN QPAASQQTMS 780
PAHVSSPVPA QMQQQQHQTQ QQPSQQVPQS QQQQVSQPQQ QTQQQQPSTP SHHLSSILNE 840
TANSNDSSTL AVAANDSNNS SSNSSTNSIV NNQPTSVHDS NSQSSINSSS NNQQQLLMDN 900
TNSHGGNSES AQNAGVDVGL FDNNSMSSNS AAVAAVASNA ASAAAALLDS NSQSSNAEFE 960
KNQSEGEGLG VVEGVIANET DLPQDENSVS KTQDITLSTE LPTIQDDLQE KPTAEMEQTQ 1020
LGQSLGDLSK SLLEEPKTVE ESGEDKSQSA PGVAPPADPI IPVTQPPQQQ MPPIGMPMHP 1080
IAPGYEAQAQ GQGHMPPMMP PYGGAPGMYP PYPMLHQQEI AALQQQIQEL YCMPPGHELQ 1140
HQDKLMRMQE RLNLLTQHEV NDQCAGGPQC LLFQNVPPMY GPPGNPLLNQ QMVESPQVSS 1200
TTGRGRGKSA NKPRKPRAKK GEKAQVGQQQ DLMDISGNVA MGAANAVSSI PTTQLPVSED 1260
CVTQGAGDTS VVGMLEYSEG MGDLSQDVHS ANELDTSTDG SGKKKKPRKP RTPKDPNKPP 1320
RDRTPKAKKP KDPNDPNSTE TPAAVKKRAG ASKRRKQYGE DGAEQTGEGS EVEDNKPLVP 1380
KAGSADGEAE TTSGGTGVDG ESPDYDDIPV SKIPRGSNED EKEAEAGDET VDSVPDSAGD 1440
PASTPSRRDR KRSTARSRRN ANSEEGGSAR KNRGSLSAKA LKKRRNRGRI VPESDGEDDT 1500
LDRTPPPSPP PDSEMDSNKR RSSRNTQRKK YIDDVMLRFS DDENSLLVAS PVKKDKKPSA 1560
NASNSNAGSD VEKTEPQSGA EGDAAQEVGE EKSNLPLDES SQLEASSSTS AVAEKERQIS 1620
TDAANAAMSS KPNYVYINTG DEDSMVVQLV LAMRMGKREL ILDKPKEKAP EPKQDEEKSE 1680
LDEATTDKPE GDEKFKTEGE SKKDLTDSEE TKLESSAMEV DSKEESEPDD SKKSDEDNKD 1740
KDKMEVDDEV GKSDKESKPE EQSETVKTEE NSKAIEEDKS STVLTADHAK EPETVLEKME 1800
VDEKANDDQS AVSKAEGSDE KSTDDSNPEE ATTEKNKESL EIEGEKERVK EGEESVKKEN 1860
DEKTEADMEN KPEPVFIDVE EYFVKYRNFS YLHCEWRTEE ELLKGDRRVA AKIRRFQQKQ 1920
SQQLNIFENI EDEPFNQDFT EVDRVLDMSV HTDETSGETT KHYLVKWKSL PYEDCTWELE 1980
EDVDNDKIEQ YLRFNKIPQR SEWKSKKRPH PELWKKLEKT PVYKGGNSLR PYQLEGLNWL 2040
KFSWYNTHNC ILADEMGLGK TIQSLTFVHS VYEYGIRGPF LVIAPLSTIP NWQREFEGWT 2100
DMNVVVYHGS VTSKQMIQDY EYYYKTESGK VLKEPIKFNV LITTFEMIVT DYMDLKAFNW 2160
RLCVIDEAHR LKNRNCKLLE GLRQLNLEHR VLLSGTPLQN NISELFSLLN FLEPSQFSSQ 2220
EEFMSEFGSL RTEEEVNKLQ ALLKPMMLRR LKDDVEKSLA PKEETIIEVE LTNIQKKYYR 2280
GILEQNFSFL KKGTTSANIP NLMNTMMELR KCCIHPYLLN GAEEQIQYDF KSQHGEDPES 2340
YYKNLILSAG KMVLIDKLLP KLKANGHRVL IFSQMVRCLD ILEDYLVYRK YPFERIDGRI 2400
RGNLRQEAID RYSKPGSDRF VFLLCTKAGG LGINLTAADT VIIYDSDWNP QNDLQAQARC 2460
HRIGQRKMVK IYRLLCRNTY EREMFDKASM KLGLDKAVLQ SMNTQGSKDG NNKQLSKKEI 2520
EDLLKKGAYG AVMDDDNAGD KFCEEDIDSI LKRRTQVITM ESEKGSTFSK ASFAASGNRS 2580
DITIDDPDFW TKWAKKVDID PDACERDETE DLVLSEPRRR TQIKRYGHED VMELNSEESS 2640
NENSDEEGGI GLRSRRRKEK RDRAREKKGN DEYIPRERDA LAALGLEEIQ YGNWAKSECF 2700
KVEKGLLSFG WGRWSELLEL GQFKRGWRDV DVEDCARIIL LYCLQVYKGD EKIKTFIWDL 2760
ITPTEDGEVQ KISRDHSGLH NLVPRGRNGG KSNKESTGVS TPAPGSASGS NSGNTTPAHK 2820
SSALDGSDKD SGGINASAVA AAVTSIHDPN HWSKKEKYDA DAYLEGAYKK HLGRHANKVL 2880
LRVRMLYYIQ HEVIGDFVQQ IKDNTPISEL PIRPPPTPDQ VPSSWWNPIC CDKSLLVGTY 2940
KHGCEMYRQM RADPNLCFVT HVGAGAAGDD LAVTSLPINE DDANSKHDDG DEVDDDGTTT 3000
TKDSDSTKLT GGDNKDSLLD PERPSSSGKS SSENASGGND KTESENDATT VSESSYKSEV 3060
LPGKGSDLDV SVAQQDALSA TPELANTSDP KMNKNDAQVS ASVSCDPADS SSPEAAGKAQ 3120
GTGVQTGDAG ELDIESEKKD NEKETKESTG DAPAVEAKKD SAAIARAEGD KTESCTNNAT 3180
TNISTTTTTT TITNTTTTTN NPSSKAANSN NTTDHANSNS HLGLDEEESV AGSYPPTVAA 3240
VEDATTMWPS MQDLNTRLRR VITAYQRNYK KEELKLQQKA KLQALVSSTP PLSVPTTPTL 3300
QSMQMQLQSG SGSGGSGIGS SAQHDASGRS LQALMQSQGA STSAAAAAAA SSAGGSCSGS 3360
GQVGMGGAGV MPAMPTAADI SLMLSILNTT DVNQLANLDI NKLAMYLVSM NNKMERQGKM 3420
ELAAKERESQ RLQLIPKKWN RREEYEFLRV LTGYGVDLHV STPMASSNGS SLSPDWTKFK 3480
QMAHLERKSD ETLTDYYKVF VAMCKRQAGL KLSESERGLE GIIEEIEKEH AKLILDRLEV 3540
LAKLREVARN PMLEERLKLC TKNADTPDWW EPGRHDKELI TAVLKHGLYR SETFIFNDPN 3600
FSFGESEKRF IRELEAQIQR TIKLEAFNAE KAEKLAAAEK DAATEKAAAT EKAAAEKAAS 3660
VKNEVIDLDD ELMTNESVIK KESPVTPIKE EIKSEESPEK HDTADNLEDK NSDAEESTKI 3720
KGKEDFNPET TEKEALDEST NLNKDKSSTE TLVPEIEDSK PSEDKMEVEE LPVAENGEKE 3780
GSPEKCSDAE DKKFSEEKPS SPAVPDGKVS EMEADEAAPN TEENCSGDSE SPEKECEDKV 3840
VEKVEEEKGE NSYEKAEEQK EETEKLEKSS IESEPSEKSE TVLEPEVAVP KKSTGDQDIL 3900
DLVAGPSDPD DDEVMKEKEK AVEEECKKQA AELKARFPDL EVIQPATVKQ QKLEKPKLEM 3960
CMIRWFKDFA LERRIAHIVA CVESGNWPVD SKYSAFATCK GATDLSIALH ESIPHLSSLE 4020
RRSTTPDVIT ITTDQGVTKH LQTSHMQQVA SSASAASTSS GVPQVTQSKP SSSNSLPGLD 4080
AKSINAAVAA AVAAAAAGGN ATSLSSLLPG MSLSAATGSS AGGVSGLSVP SAGSGVGKKR 4140
KRHIAIDVET ERAKLHALLN SSTMAPKDWE SEIANMEALS GSSGRGRGGN SSASSGMQPP 4200
PAHQHASLSR QSSGQFSKPA VPAMKTPPPS MGAPMDLSSS LPKMNMTEML KSASSSGAID 4260
LSEVQDFSMP SKKSSVHAAL SSAFPSMGNK SKLDDTLNKL MKKNNCTIEE PVIGKEKKRK 4320
KLDEIVLGLS AAKEQKTFPD PSLPSSKKPQ IPPSVSVTPA NLQSSSNQQS NQKPFTITVT 4380
TVPGKSKSGS SNSGSGTGGS SSASGGGAGG SGLSALQNMA MGGLSSKDSL NALLAQTMAT 4440
DPQTFLKQQQ KMMQFLPPAQ RKAYENMLAE MEQAMKISSK FSTNSPHDVK VNKWLSDMTS 4500
PLGDQLSIDY VGGGGASGSG SGNSRRSNRQ QGNSQQSSSA AQLQKQQQQQ QQQQQQQQQH 4560
SMPGPQNLTG EEPVPVINKQ TGKRLGGNKA PQLKRLMQWL TENPNYEVDP KWLEQMQNPM 4620
STPSPRPASM ESGYGSSAVK SHGGRPLSNL SSTSSSSHTQ QQSSAAQSQA GGNSGSSKKN 4680
SRQQTAASAA LDQAALQFGS LAGLNPSLLA NLPGLGAFDP KNPLAAFDPK NPLLSMSFGG 4740
MPGMGNIPGL GNLNNMNLFA SLAGMGGLGN LAGMDTQSLA ALMAAAGPTL GGLTGASGGA 4800
GSGKSQAQSQ SSATSSSSSA SKKKQQQQQQ QAQNEAAQLA AAISASTGGS GASGGKNAAA 4860
SASQLAAGFP FLFPNPSLLY PPMGLGGLNP YSLGSSGLGS AYDQLAQQYN LLNGATSSAS 4920
NTSSTQSKSH QSQSKSSQSR NTTASANSAA SLMNAMASMG GGASTVTTPS TSASGSGRGR 4980
QSSSRNQSQT TPTAADMAQL SSLLMPGADP HLLESLSRMS NMDLAQATRL MSSLGMPPLS 5040
GTPSSSGGGN TSTSKRSSQA ANEANVQAKE QQKWLESLAR GALPTDLAAL QAFSQGKMPS 5100
TSGSNTGTST SSSKSSKAAA TAAAAQLPQI PGMSSDFPQA FLAEMAAQAM AAAGGSLPLS 5160
GPGSLASLAG LTGGSAGGGG SSASGSTSHS SSKRQREQDA FKQQMDYYTK TLGLGSGISL 5220
IPTSSAGGSS ASSSAANAAA AAYAAALDAE QQHQQQQKAL SKRARGDLHP TKEELAALAA 5280
GLPLNLGASM SSIEKSLRGG SSSSSSSTPA PMTAEQDKVT LTPLNASGGG SGSSSSSAAA 5340
AGLAANLPSQ TTITIAPPIS SGASTSSERS ERSESRISLT ITNAADAAKL PPPYEEADEL 5400
IIQPILKKPT AANPGSSHGG SVDDLDTAEN TSAANLSGSS SSSAAAAAAA AAEENRRSSN 5460
RLKRPRSGNE QGSGSVEGQP PEKRRELRST RHTRSSADAS TLNLSTGSES GAEERNE 5517 
Gene Ontology
 GO:0005875; C:microtubule associated complex; IDA:FlyBase.
 GO:0005634; C:nucleus; IDA:FlyBase.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0016887; F:ATPase activity; IEA:EC.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0004386; F:helicase activity; IEA:InterPro.
 GO:0019730; P:antimicrobial humoral response; IMP:FlyBase.
 GO:0006200; P:ATP catabolic process; IEA:GOC.
 GO:0007411; P:axon guidance; IMP:FlyBase.
 GO:0007350; P:blastoderm segmentation; IMP:FlyBase.
 GO:0007298; P:border follicle cell migration; IMP:FlyBase.
 GO:0008340; P:determination of adult lifespan; IMP:FlyBase.
 GO:0007476; P:imaginal disc-derived wing morphogenesis; IMP:FlyBase.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IMP:FlyBase.
 GO:0016322; P:neuron remodeling; IMP:FlyBase.
 GO:0007031; P:peroxisome organization; IMP:FlyBase.
 GO:0046622; P:positive regulation of organ growth; IMP:FlyBase.
 GO:0007379; P:segment specification; IMP:FlyBase.
 GO:0007614; P:short-term memory; IMP:FlyBase. 
Interpro
 IPR006576; BRK_domain.
 IPR023780; Chromo_domain.
 IPR000953; Chromo_domain/shadow.
 IPR016197; Chromodomain-like.
 IPR014001; Helicase_ATP-bd.
 IPR001650; Helicase_C.
 IPR027417; P-loop_NTPase.
 IPR000330; SNF2_N. 
Pfam
 PF07533; BRK
 PF00385; Chromo
 PF00271; Helicase_C
 PF00176; SNF2_N 
SMART
 SM00592; BRK
 SM00298; CHROMO
 SM00487; DEXDc
 SM00490; HELICc 
PROSITE
 PS50013; CHROMO_2
 PS51192; HELICASE_ATP_BIND_1
 PS51194; HELICASE_CTER 
PRINTS