CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013143
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein transport protein Sec31A 
Protein Synonyms/Alias
 SEC31-like protein 1; SEC31-related protein A 
Gene Name
 Sec31a 
Gene Synonyms/Alias
 Sec31l1 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
71SSSHRYHKLIWGPHKacetylation[1]
111SKIIAGDKEVVIAQKubiquitination[2]
206RKNEPIIKVSDHSNRubiquitination[2]
435ISQVVTEKDFLNRSAubiquitination[2]
470ASQTEFEKNVWSFLKubiquitination[2]
487FEEDSRGKYLELLGYubiquitination[2]
502RKEDLGQKIALALNKubiquitination[2]
509KIALALNKVDGPDVAubiquitination[2]
646IVESCDLKNWREALAubiquitination[2]
706RLVACWTKAQDGSSPubiquitination[2]
722SLQDLIEKVVILRKAubiquitination[2]
728EKVVILRKAVQLTQAubiquitination[2]
791RLCKAQGKPVSGQESubiquitination[2]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity). 
Sequence Annotation
 REPEAT 4 47 WD 1.
 REPEAT 64 111 WD 2.
 REPEAT 120 160 WD 3.
 REPEAT 166 206 WD 4.
 REPEAT 209 254 WD 5.
 REPEAT 258 298 WD 6.
 REPEAT 301 342 WD 7.
 REPEAT 397 429 WD 8; interaction with SEC13 (By
 REGION 161 470 Interaction with SEC13 (By similarity).
 REGION 799 1123 Interaction with PDCD6 (By similarity).
 MOD_RES 526 526 Phosphoserine.
 MOD_RES 531 531 Phosphoserine (By similarity).
 MOD_RES 798 798 Phosphoserine (By similarity).
 MOD_RES 1171 1171 Phosphothreonine (By similarity).
 MOD_RES 1173 1173 Phosphoserine (By similarity).
 CROSSLNK 646 646 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 1227 1227 Glycyl lysine isopeptide (Lys-Gly)  
Keyword
 Alternative splicing; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Endoplasmic reticulum; ER-Golgi transport; Isopeptide bond; Membrane; Phosphoprotein; Protein transport; Reference proteome; Repeat; Transport; Ubl conjugation; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1230 AA 
Protein Sequence
MKLKEIDRTA MQAWSPAQNH PIYLATGTSA QQLDATFSTN ASLEIFELDL SDPSLDMKSC 60
ATFSSSHRYH KLIWGPHKMD SKGDVSGVLI AGGENGNIIL YDPSKIIAGD KEVVIAQKDK 120
HTGPVRALDV NIFQTNLVAS GANESEIYIW DLNNFATPMT PGAKTQPPED ISCIAWNRQV 180
QHILASASPS GRATVWDLRK NEPIIKVSDH SNRMHCSGLA WHPDVATQMV LASEDDRLPV 240
IQMWDLRFAS SPLRVLENHA RGILAVAWSM ADPELLLSCG KDAKILCSNP NTGEVLYELP 300
TNTQWCFDIQ WCPRNPAVLS AASFDGRISV YSIMGGSIDG LRQKQVDKLS SSFGNLDPFG 360
TGQPLPPLQI PQQSAQHSIV LPLKKPPKWI RRPVGASFSF GGKLVTFESV AVPLQQGAEQ 420
QRRQPVFISQ VVTEKDFLNR SAQLQHAVQS QGFIGYCQKK IEASQTEFEK NVWSFLKVNF 480
EEDSRGKYLE LLGYRKEDLG QKIALALNKV DGPDVALKDS DQVAQSDGEE SPAAEEQLLG 540
ERIKEEKQEC DFLPSAGGTF NISVSGDIDG LITRALLTGN FESAVDLCLH DNRMADAIIL 600
AIAGGQELLA QTQKKYFAKS QSKITRLITA VVMKNWREIV ESCDLKNWRE ALAAVLTYAK 660
PDEFSALCDL LGTRLEREGD SLLRTQACLC YICAGNVERL VACWTKAQDG SSPLSLQDLI 720
EKVVILRKAV QLTQALDTNT VGALLAEKMS QYASLLAAQG SIAAALAFLP DNTNQPNIVQ 780
LRDRLCKAQG KPVSGQESSQ SPYERQPLSK GRPGPVAGHS QMPRVQTQQY YPHGENPPPP 840
GFIMQGNVIP NPAAPLPTAP GHMPSQLPPY PQPQPYQPAQ QYSFGTGGAA AYRPQQPVAP 900
PASNAYPNTP YISPVASYSG QPQMYTAQQA SSPTSSSAAS FPPPSSGASF QHGGPGAPPS 960
SSAYALPPGT TGTPPAASEL PASQRTENQS FQDQASILEG PQNGWNDPPA LNRVPKKKKM 1020
PENFMPPVPI TSPIMNPSGD PQSQGLQQQP STPGPLSSHA SFPQQHLAGG QPFHGVQQPL 1080
AQTGMPPSFS KPNTEGAPGA PIGNTIQHVQ ALPTEKITKK PIPEEHLILK TTFEDLIQRC 1140
LSSATDPQTK RKLDDASKRL EFLYDKLREQ TLSPTIINGL HSIARSIETR NYSEGLSVHT 1200
HIVSTSNFSE TSAFMPVLKV VLSQASKLGV 1230 
Gene Ontology
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0030134; C:ER to Golgi transport vesicle; ISS:UniProtKB.
 GO:0012507; C:ER to Golgi transport vesicle membrane; IEA:UniProtKB-SubCell.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0051592; P:response to calcium ion; IEA:Compara.
 GO:0016192; P:vesicle-mediated transport; IEA:UniProtKB-KW. 
Interpro
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF00400; WD40 
SMART
 SM00320; WD40 
PROSITE
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS