CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030965
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein CHURC1-FNTB 
Protein Synonyms/Alias
 cDNA FLJ59570, highly similar to Protein farnesyltransferase subunit beta (EC 2.5.1.58) 
Gene Name
 CHURC1-FNTB 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
47LITNKSLKEEDGEEIubiquitination[1]
88FQAKVEEKIQEVFSSubiquitination[1]
97QEVFSSYKFNHLVPRubiquitination[1, 2, 3, 4]
210YDIINREKLLQYLYSubiquitination[5]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [5] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; Repeat; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 471 AA 
Protein Sequence
MCGDCVEKEY PNRGNTCLEN GSFLLNFTGC AVCSKRDFML ITNKSLKEED GEEIVTYDHL 60
CKNCHHVIAR HEYTFSIMDE FQAKVEEKIQ EVFSSYKFNH LVPRLVLQRE KHFHYLKRGL 120
RQLTDAYECL DASRPWLCYW ILHSLELLDE PIPQIVATDV CQFLELCQSP EGGFGGGPGQ 180
YPHLAPTYAA VNALCIIGTE EAYDIINREK LLQYLYSLKQ PDGSFLMHVG GEVDVRSAYC 240
AASVASLTNI ITPDLFEGTA EWIARCQNWE GGIGGVPGME AHGGYTFCGL AALVILKRER 300
SLNLKSLLQW VTSRQMRFEG GFQGRCNKLV DGCYSFWQAG LLPLLHRALH AQGDPALSMS 360
HWMFHQQALQ EYILMCCQCP AGGLLDKPGK SRDFYHTCYC LSGLSIAQHF GSGAMLHDVV 420
LGVPENALQP THPVYNIGPD KVIQATTYFL QKPVPGFEEL KDETSAEPAT D 471 
Gene Ontology
 GO:0005965; C:protein farnesyltransferase complex; IEA:InterPro.
 GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0007275; P:multicellular organismal development; IEA:InterPro.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IEA:InterPro.
 GO:0018343; P:protein farnesylation; IEA:InterPro.
 GO:0042127; P:regulation of cell proliferation; IEA:InterPro. 
Interpro
 IPR026872; FTB.
 IPR001330; Prenyltrans.
 IPR008930; Terpenoid_cyclase/PrenylTrfase.
 IPR009508; Transcrpt_activator_Churchill. 
Pfam
 PF06573; Churchill
 PF00432; Prenyltrans 
SMART
  
PROSITE
  
PRINTS