CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-025075
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 m7GpppX diphosphatase 
Protein Synonyms/Alias
  
Gene Name
 Dcps 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
127PRHLSDIKTTVVYPAubiquitination[1]
137VVYPATEKHLQKYMRacetylation[2, 3, 4, 5]
137VVYPATEKHLQKYMRubiquitination[1]
141ATEKHLQKYMRQDLRacetylation[3]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
 Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
 J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379]
 [3] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [5] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 291 AA 
Protein Sequence
MADTAPQLKR KREQEAEEAE TPSTEEKEAG VGNGTSAPVR LPFSGFRVQK VLRESARDKI 60
IFLHGKVNED SGDTHGEDAV VILEKTPFQV EHVAQLLTGS PELKLQFSND IYSTYNLFPP 120
RHLSDIKTTV VYPATEKHLQ KYMRQDLRLI RETGDDYRTI TLPYLESQSL SIQWVYNILD 180
KKAEADRIVF ENPDPSDGFV LIPDLKWNQQ QLDDLYLIAI CHRRGIRSLR DLTPEHLPLL 240
RNILREGQRP EQGGWEKGTS ANLSAFFFCK EPCGSLSPSS HSQHLFHLPS S 291 
Gene Ontology
 GO:0016787; F:hydrolase activity; IEA:InterPro.
 GO:0000290; P:deadenylation-dependent decapping of nuclear-transcribed mRNA; IEA:InterPro. 
Interpro
 IPR008594; DcpS/DCS2.
 IPR011146; HIT-like.
 IPR011145; Scavenger_mRNA_decap_enz_N. 
Pfam
 PF05652; DcpS 
SMART
  
PROSITE
  
PRINTS