UniProt Accession

 PDGFD_HUMAN; Q9GZP0; A8K9T6; Q9BWV5 

Genbank Protein ID

 AB033832; AF336376; AF335584; AY027517; AY027518; AF113216; AY359116; AK292801; CH471065; BC030645 

Genbank Nucleotide ID

 BAB18903.1; AAK56136.1; AAK38840.1; AAK20081.1; AAK20082.1; AAG39287.1; AAQ89474.1; BAF85490.1; EAW67045.1; AAH30645.1 

Protein Name

 Platelet-derived growth factor D 

Protein Synonyms/Alias

 PDGF-D; Iris-expressed growth factor; Spinal cord-derived growth factor B; SCDGF-B; Platelet-derived growth factor D, latent form; PDGFD latent form; Platelet-derived growth factor D, receptor-binding form; PDGFD receptor-binding form 

Gene Name

 PDGFD 

Gene Synonyms/Alias

 IEGF; SCDGFB; MSTP036; UNQ1899/PRO4345 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
160	SDDYFVAKPGFKIYY	ubiquitination	[1, 2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix (By similarity). 

Sequence Annotation

 DOMAIN 52 170 CUB.
 CARBOHYD 276 276 N-linked (GlcNAc...) (Potential).
 DISULFID 109 131 By similarity.
 DISULFID 296 296 Interchain (By similarity).
 DISULFID 302 360 By similarity.
 DISULFID 306 362 By similarity.  

Keyword

 Alternative splicing; Cleavage on pair of basic residues; Complete proteome; Developmental protein; Disulfide bond; Glycoprotein; Growth factor; Mitogen; Polymorphism; Proto-oncogene; Reference proteome; Secreted; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 370 AA 

Protein Sequence

Gene Ontology

 GO:0005788; C:endoplasmic reticulum lumen; TAS:Reactome.
 GO:0005576; C:extracellular region; TAS:Reactome.
 GO:0000139; C:Golgi membrane; TAS:Reactome.
 GO:0071230; P:cellular response to amino acid stimulus; IEA:Compara.
 GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
 GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
 GO:0050730; P:regulation of peptidyl-tyrosine phosphorylation; IEA:Compara. 

Interpro

 IPR000859; CUB_dom.
 IPR000072; PD_growth_factor.
 IPR027123; PDGFD. 

Pfam

 PF00431; CUB
 PF00341; PDGF 

SMART

 SM00042; CUB
 SM00141; PDGF 

PROSITE

 PS01180; CUB
 PS00249; PDGF_1
 PS50278; PDGF_2 

PRINTS