UniProt Accession

 E5RIJ0_HUMAN; E5RIJ0 

Genbank Protein ID

 AC083973; AC107885 

Genbank Nucleotide ID

  

Protein Name

 DNA polymerase beta 

Protein Synonyms/Alias

  

Gene Name

 POLB 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
72	VGTKIAEKIDEFLAT	acetylation	[1, 2]
113	IGPSAARKFVDEGIK	ubiquitination	[3]
141	HHQRIGLKYFGDFEK	ubiquitination	[3]
148	KYFGDFEKRIPREEM	ubiquitination	[3]

Reference

 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 193 AA 

Protein Sequence

Gene Ontology

 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0003887; F:DNA-directed DNA polymerase activity; IEA:InterPro.
 GO:0006281; P:DNA repair; IEA:InterPro. 

Interpro

 IPR002054; DNA-dir_DNA_pol_X.
 IPR010996; DNA_pol_b-like_N.
 IPR018944; DNA_pol_lambd_fingers_domain.
 IPR002008; DNA_pol_X_beta-like.
 IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
 IPR027420; PolB_N. 

Pfam

 PF10391; DNA_pol_lambd_f 

SMART

 SM00278; HhH1
 SM00483; POLXc 

PROSITE

  

PRINTS

 PR00870; DNAPOLXBETA.