UniProt Accession

 MAP11_HUMAN; P53582; B4E2E6 

Genbank Protein ID

 D42084; AK304239; CH471057; BC030054 

Genbank Nucleotide ID

 BAA07679.1; BAG65108.1; EAX06083.1; AAH30054.1 

Protein Name

 Methionine aminopeptidase 1 

Protein Synonyms/Alias

 MAP 1; MetAP 1; Peptidase M 1 

Gene Name

 METAP1 

Gene Synonyms/Alias

 KIAA0094 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
19	DGCSSEAKLQCPTCI	ubiquitination	[1]
123	SESEQALKGTSQIKL	ubiquitination	[2]
129	LKGTSQIKLLSSEDI	ubiquitination	[2, 3]
158	DVAAGMIKPGVTTEE	ubiquitination	[1]
278	ELGNIIQKHAQANGF	ubiquitination	[1, 2, 3]
311	PNVPHYAKNKAVGVM	ubiquitination	[2, 3]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Required for normal progression through the cell cycle. 

Sequence Annotation

 REGION 9 52 Zinc finger-like; important for proper
 METAL 220 220 Divalent metal cation 1.
 METAL 231 231 Divalent metal cation 1.
 METAL 231 231 Divalent metal cation 2; catalytic.
 METAL 294 294 Divalent metal cation 2; catalytic; via
 METAL 327 327 Divalent metal cation 2; catalytic.
 METAL 358 358 Divalent metal cation 1.
 METAL 358 358 Divalent metal cation 2; catalytic.
 BINDING 203 203 Substrate.
 BINDING 301 301 Substrate.
 MOD_RES 2 2 N-acetylalanine.  

Keyword

 3D-structure; Acetylation; Aminopeptidase; Complete proteome; Cytoplasm; Hydrolase; Metal-binding; Protease; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 386 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; TAS:HGNC.
 GO:0004177; F:aminopeptidase activity; TAS:UniProtKB.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0008235; F:metalloexopeptidase activity; TAS:UniProtKB.
 GO:0031365; P:N-terminal protein amino acid modification; TAS:HGNC.
 GO:0018206; P:peptidyl-methionine modification; TAS:HGNC.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
 GO:0006417; P:regulation of translation; TAS:HGNC. 

Interpro

 IPR001714; Pept_M24_MAP.
 IPR000994; Pept_M24_structural-domain.
 IPR002467; Pept_M24A_MAP1. 

Pfam

 PF00557; Peptidase_M24 

SMART

  

PROSITE

 PS00680; MAP_1 

PRINTS

 PR00599; MAPEPTIDASE.