CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-034102
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Phosphatidylinositol 3-kinase, catalytic, alpha polypeptide, isoform CRA_a 
Protein Synonyms/Alias
 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 
Gene Name
 Pik3ca 
Gene Synonyms/Alias
 mCG_20268 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
598INLTDILKQEKKDETubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 946 AA 
Protein Sequence
MPVCEFDMVK DPEVQDFRRN ILNVCKEAVD LRDLNSPHSR AMYVYPPNVE SSPELPKHIY 60
NKLDKGQIIV VIWVIVSPNN DKQKYTLKIN HDCVPEQVIA EAIRKKTRSM LLSSEQLKLC 120
VLEYQGKYIL KVCGCDEYFL EKYPLSQYKY IRSCIMLGRM PNLMLMAKES LYSQLPIDSF 180
TMPSYSRRIS TATPYMNGET STKSLWVINS ALRIKILCAT YVNVNIRDID KIYVRTGIYH 240
GGEPLCDNVN TQRVPCSNPR WNEWLNYDIY IPDLPRAARL CLSICSVKGR KGAKEEHCPL 300
AWGNINLFDY TDTLVSGKMA LNLWPVPHGL EDLLNPIGVT GSNPNKETPC LELEFDWFSS 360
VVKFPDMSVI EEHANWSVSR EAGFSYSHTG LSNRLARDNE LRENDKEQLR ALCTRDPLSE 420
ITEQEKDFLW SHRHYCVTIP EILPKLLLSV KWNSRDEVAQ MYCLVKDWPP IKPEQAMELL 480
DCNYPDPMVR SFAVRCLEKY LTDDKLSQYL IQLVQVLKYE QYLDNLLVRF LLKKALTNQR 540
IGHFFFWHLK SEMHNKTVSQ RFGLLLESYC RACGMYLKHL NRQVEAMEKL INLTDILKQE 600
KKDETQKVQM KFLVEQMRQP DFMDALQGFL SPLNPAHQLG NLRLEECRIM SSAKRPLWLN 660
WENPDIMSEL LFQNNEIIFK NGDDLRQDML TLQIIRIMEN IWQNQGLDLR MLPYGCLSIG 720
DCVGLIEVVR NSHTIMQIQC KGGLKGALQF NSHTLHQWLK DKNKGEIYDA AIDLFTRSCA 780
GYCVATFILG IGDRHNSNIM VKDDGQLFHI DFGHFLDHKK KKFGYKRERV PFVLTQDFLI 840
VISKGAQEYT KTREFERFQE MCYKAYLAIR QHANLFINLF SMMLGSGMPE LQSFDDIAYI 900
RKTLALDKTE QEALEYFTKQ MNDAHHGGWT TKMDWIFHTI KQHALN 946 
Gene Ontology
 GO:0005943; C:1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex; IEA:Compara.
 GO:0030027; C:lamellipodium; IDA:MGI.
 GO:0005942; C:phosphatidylinositol 3-kinase complex; IPI:MGI.
 GO:0005886; C:plasma membrane; IBA:RefGenome.
 GO:0016303; F:1-phosphatidylinositol-3-kinase activity; IDA:MGI.
 GO:0035005; F:1-phosphatidylinositol-4-phosphate 3-kinase activity; IBA:RefGenome.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0046934; F:phosphatidylinositol-4,5-bisphosphate 3-kinase activity; IBA:RefGenome.
 GO:0006006; P:glucose metabolic process; IMP:MGI.
 GO:2000811; P:negative regulation of anoikis; IEA:Compara.
 GO:0043066; P:negative regulation of apoptotic process; IDA:MGI.
 GO:0048015; P:phosphatidylinositol-mediated signaling; IEA:InterPro.
 GO:0043491; P:protein kinase B signaling cascade; IMP:MGI.
 GO:0006468; P:protein phosphorylation; IDA:MGI.
 GO:0040014; P:regulation of multicellular organism growth; IMP:MGI. 
Interpro
 IPR016024; ARM-type_fold.
 IPR000008; C2_Ca-dep.
 IPR008973; C2_Ca/lipid-bd_dom_CaLB.
 IPR011009; Kinase-like_dom.
 IPR000403; PI3/4_kinase_cat_dom.
 IPR018936; PI3/4_kinase_CS.
 IPR002420; PI3K_C2_dom.
 IPR000341; PI3K_Ras-bd_dom.
 IPR015433; PI_Kinase.
 IPR001263; PInositide-3_kin_accessory_dom. 
Pfam
 PF00454; PI3_PI4_kinase
 PF00792; PI3K_C2
 PF00794; PI3K_rbd
 PF00613; PI3Ka 
SMART
 SM00239; C2
 SM00142; PI3K_C2
 SM00144; PI3K_rbd
 SM00145; PI3Ka
 SM00146; PI3Kc 
PROSITE
 PS00915; PI3_4_KINASE_1
 PS00916; PI3_4_KINASE_2
 PS50290; PI3_4_KINASE_3
 PS51547; PI3K_C2
 PS51546; PI3K_RBD
 PS51545; PIK_HELICAL 
PRINTS