CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019687
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Uncharacterized WD repeat-containing protein YOL087C 
Protein Synonyms/Alias
  
Gene Name
 YOL087C; O0944 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
355LSSYEDAKLTRIFKPubiquitination[1]
450HVITENTKGQMQRWDubiquitination[1]
798EQIQESYKQQYMNTSubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, VillĂ©n J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301
Functional Description
 Involved in the resistance to phenanthroline, sanguinarine, nordihydroguaiaretic acid (NDGA), isopropyl (N-3- chloro-phenyl)-carbamate (IPCPC) and guanosine 5'-O-(2- thiodiphosphate). 
Sequence Annotation
 REPEAT 21 62 WD 1.
 REPEAT 91 132 WD 2.
 REPEAT 160 200 WD 3.
 REPEAT 219 262 WD 4.
 REPEAT 266 305 WD 5.
 REPEAT 387 426 WD 6.
 REPEAT 428 466 WD 7.
 MOD_RES 668 668 Phosphoserine.
 MOD_RES 693 693 Phosphothreonine.  
Keyword
 Complete proteome; Cytoplasm; Phosphoprotein; Reference proteome; Repeat; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1116 AA 
Protein Sequence
MNQLTVSYGL ISPDYCTSQD AHILPITKIL YPDIPGKNYF LTSGRDGSII LHKNTQLSNE 60
PETAATTIKN DAIRMQVHSD WASDLIHVNM KNSDPSAGDT FISVSHDFSI VLISVNAQLT 120
TWDKKIIGDH DDYIKCIVPI HYEMSNDYEL EEQEGGPDNV HDGINNGIVV DEQNNFLFVT 180
GGLDRKIKLW CLSSGPEKMA TLLHTFDNAQ SNDTGSIYSM SPIIPKYSFD DNQTSRPFDF 240
VAGDCNGDLI FYSCKYRKEV IRIQNAHRTN IKVVRTLDDS TRLISTSSDG VINVWDLNCR 300
HDQTTGALQL PKKIGSWSWD SSIWCVQGTS LDKLYFGDSQ GNVMRANLSS YEDAKLTRIF 360
KPDHHHHHHH HHEHEEQNIS TTDAKVKKYG GILDIALLPN EKLLFSFCTD SNLNVLDLTN 420
NHFSVNEGGF ALTRSSLLTN RRHVITENTK GQMQRWDIVS CELLNTFDSS EGSFDDIVMK 480
YTSKEILSHW CTVSVKVGML FVKINPKFLK TEVYGSALKD YQVVNNIEIN SDERYNLGKI 540
VINSLFNEFI SYEVQKDKLL RKKIFSLKKK DLTNSLTLDT GYNSESKKNN KDKKRKSTFK 600
ISSTLSIGNT NSSGTPPNSA PATPVMAETI VLEEQPLLQS ASDKAIDDSL ELVQPLPASK 660
KPYFRTQSSG SLLSRKFKSF RSTSGRATTG LNTPEEPKGI LPDTPHVIND DSAFPQAINT 720
TQQSKDATPE SMLWNHPFKL EQKLSAISSQ DLPSNNTHNK LRSSENSRAN STSTLEGNEK 780
KKPEFMPDLL EQIQESYKQQ YMNTSSLKYL TKRLPVTKII KASSCPIIRV KSATLVLVHL 840
WKEGSCGGRV LFSTLLPPSH VDNETVSGGK ENSKPPDDEE VDLQAVDDDK LGKYDLIDGE 900
LGSRLNRRQI FEQLEENLPY WFAKALFRDI KTVEEQPKLN FLIMPWSSVG GSEAAGNENK 960
KKFISASDTT ESSGNDSSDS SLGNGNEAVS PSTQQQFHNM LKFGRPKTSE QELNPTDLPR 1020
ISEANVKLVA PGMIRVKKIK LYVADRFETK TPEMKAKMEP SLWLDLLCRG QVLDNDMTLN 1080
TVRTLYWKSQ GDIVLEYRRK VHNSPLVHEV NGNEGK 1116 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0043130; F:ubiquitin binding; IDA:SGD. 
Interpro
 IPR021772; DUF3337.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF11816; DUF3337
 PF00400; WD40 
SMART
 SM00320; WD40 
PROSITE
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS