CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008403
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Fatty aldehyde dehydrogenase 
Protein Synonyms/Alias
 Aldehyde dehydrogenase 10; Aldehyde dehydrogenase family 3 member A2; Microsomal aldehyde dehydrogenase 
Gene Name
 ALDH3A2 
Gene Synonyms/Alias
 ALDH10; FALDH 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
266WKIKETVKEFYGENIubiquitination[1]
274EFYGENIKESPDYERubiquitination[2]
299LSLLEGQKIAFGGETubiquitination[2]
324VLTDVDPKTKVMQEEubiquitination[2]
326TDVDPKTKVMQEEIFubiquitination[2]
452QSKVDWGKFFLLKRFubiquitination[1]
457WGKFFLLKRFNKEKLubiquitination[1]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid. 
Sequence Annotation
 NP_BIND 185 190 NAD (Potential).
 ACT_SITE 207 207 By similarity.
 ACT_SITE 241 241 By similarity.  
Keyword
 Alternative splicing; Complete proteome; Direct protein sequencing; Disease mutation; Endoplasmic reticulum; Ichthyosis; Membrane; Mental retardation; NAD; Oxidoreductase; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 485 AA 
Protein Sequence
MELEVRRVRQ AFLSGRSRPL RFRLQQLEAL RRMVQEREKD ILTAIAADLC KSEFNVYSQE 60
VITVLGEIDF MLENLPEWVT AKPVKKNVLT MLDEAYIQPQ PLGVVLIIGA WNYPFVLTIQ 120
PLIGAIAAGN AVIIKPSELS ENTAKILAKL LPQYLDQDLY IVINGGVEET TELLKQRFDH 180
IFYTGNTAVG KIVMEAAAKH LTPVTLELGG KSPCYIDKDC DLDIVCRRIT WGKYMNCGQT 240
CIAPDYILCE ASLQNQIVWK IKETVKEFYG ENIKESPDYE RIINLRHFKR ILSLLEGQKI 300
AFGGETDEAT RYIAPTVLTD VDPKTKVMQE EIFGPILPIV PVKNVDEAIN FINEREKPLA 360
LYVFSHNHKL IKRMIDETSS GGVTGNDVIM HFTLNSFPFG GVGSSGMGAY HGKHSFDTFS 420
HQRPCLLKSL KREGANKLRY PPNSQSKVDW GKFFLLKRFN KEKLGLLLLT FLGIVAAVLV 480
KAEYY 485 
Gene Ontology
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0043231; C:intracellular membrane-bounded organelle; IDA:UniProtKB.
 GO:0005743; C:mitochondrial inner membrane; IEA:Compara.
 GO:0005777; C:peroxisome; IDA:UniProtKB.
 GO:0004029; F:aldehyde dehydrogenase (NAD) activity; IDA:UniProtKB.
 GO:0004030; F:aldehyde dehydrogenase [NAD(P)+] activity; IEA:InterPro.
 GO:0046577; F:long-chain-alcohol oxidase activity; IDA:UniProtKB.
 GO:0050061; F:long-chain-aldehyde dehydrogenase activity; IDA:UniProtKB.
 GO:0052814; F:medium-chain-aldehyde dehydrogenase activity; IDA:UniProtKB.
 GO:0006081; P:cellular aldehyde metabolic process; IDA:UniProtKB.
 GO:0007417; P:central nervous system development; IMP:UniProtKB.
 GO:0008544; P:epidermis development; IMP:UniProtKB.
 GO:0007422; P:peripheral nervous system development; IMP:UniProtKB.
 GO:0033306; P:phytol metabolic process; IMP:UniProtKB.
 GO:0006714; P:sesquiterpenoid metabolic process; IDA:UniProtKB. 
Interpro
 IPR016161; Ald_DH/histidinol_DH.
 IPR016163; Ald_DH_C.
 IPR016160; Ald_DH_CS.
 IPR016162; Ald_DH_N.
 IPR015590; Aldehyde_DH_dom.
 IPR012394; Aldehyde_DH_NAD(P). 
Pfam
 PF00171; Aldedh 
SMART
  
PROSITE
 PS00070; ALDEHYDE_DEHYDR_CYS
 PS00687; ALDEHYDE_DEHYDR_GLU 
PRINTS