CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022489
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ankycorbin 
Protein Synonyms/Alias
 Ankyrin repeat and coiled-coil structure-containing protein; Novel retinal pigment epithelial cell protein; Retinoic acid-induced protein 14 
Gene Name
 RAI14 
Gene Synonyms/Alias
 KIAA1334; NORPEG 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
510LSVQKQMKLGLVSPEubiquitination[1]
603EKAFLFEKYQEAQEEubiquitination[2]
915SYSTSSSKRQSQQLEubiquitination[1, 3]
940NQLAECKKQHQEVISubiquitination[2]
967QMDEDVQKVLKQILTubiquitination[2]
970EDVQKVLKQILTMCKubiquitination[3]
Reference
 [1] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 
Functional Description
  
Sequence Annotation
 REPEAT 18 51 ANK 1.
 REPEAT 52 81 ANK 2.
 REPEAT 85 114 ANK 3.
 REPEAT 118 147 ANK 4.
 REPEAT 151 180 ANK 5.
 REPEAT 184 213 ANK 6.
 REPEAT 217 247 ANK 7.
 MOTIF 270 276 Nuclear localization signal (Probable).
 MOD_RES 249 249 Phosphothreonine.
 MOD_RES 293 293 Phosphoserine.
 MOD_RES 295 295 Phosphothreonine.
 MOD_RES 297 297 Phosphothreonine.
 MOD_RES 300 300 Phosphoserine.
 MOD_RES 340 340 Phosphoserine.
 MOD_RES 341 341 Phosphoserine.
 MOD_RES 358 358 Phosphoserine.
 MOD_RES 512 512 Phosphoserine.
 MOD_RES 515 515 Phosphoserine.  
Keyword
 Alternative splicing; ANK repeat; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 980 AA 
Protein Sequence
MQPTYLPWLS AKEKKTNEWN KNDDRLLQAV ENGDAEKVAS LLGKKGASAT KHDSEGKTAF 60
HLAAAKGHVE CLRVMITHGV DVTAQDTTGH SALHLAAKNS HHECIRKLLQ SKCPAESVDS 120
SGKTALHYAA AQGCLQAVQI LCEHKSPINL KDLDGNIPLL LAVQNGHSEI CHFLLDHGAD 180
VNSRNKSGRT ALMLACEIGS SNAVEALIKK GADLNLVDSL GYNALHYSKL SENAGIQSLL 240
LSKISQDADL KTPTKPKQHD QVSKISSERS GTPKKRKAPP PPISPTQLSD VSSPRSITST 300
PLSGKESVFF AEPPFKAEIS SIRENKDRLS DSTTGADSLL DISSEADQQD LLSLLQAKVA 360
SLTLHNKELQ DKLQAKSPKE AEADLSFDSY HSTQTDLGPS LGKPGETSPP DSKSSPSVLI 420
HSLGKSTTDN DVRIQQLQEI LQDLQKRLES SEAERKQLQV ELQSRRAELV CLNNTEISEN 480
SSDLSQKLKE TQSKYEEAMK EVLSVQKQMK LGLVSPESMD NYSHFHELRV TEEEINVLKQ 540
DLQNALEESE RNKEKVRELE EKLVEREKGT VIKPPVEEYE EMKSSYCSVI ENMNKEKAFL 600
FEKYQEAQEE IMKLKDTLKS QMTQEASDEA EDMKEAMNRM IDELNKQVSE LSQLYKEAQA 660
ELEDYRKRKS LEDVTAEYIH KAEHEKLMQL TNVSRAKAED ALSEMKSQYS KVLNELTQLK 720
QLVDAQKENS VSITEHLQVI TTLRTAAKEM EEKISNLKEH LASKEVEVAK LEKQLLEEKA 780
AMTDAMVPRS SYEKLQSSLE SEVSVLASKL KESVKEKEKV HSEVVQIRSE VSQVKREKEN 840
IQTLLKSKEQ EVNELLQKFQ QAQEELAEMK RYAESSSKLE EDKDKKINEM SKEVTKLKEA 900
LNSLSQLSYS TSSSKRQSQQ LEALQQQVKQ LQNQLAECKK QHQEVISVYR MHLLYAVQGQ 960
MDEDVQKVLK QILTMCKNQS QKK 983 
Gene Ontology
 GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.
 GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. 
Interpro
 IPR002110; Ankyrin_rpt.
 IPR020683; Ankyrin_rpt-contain_dom. 
Pfam
 PF12796; Ank_2 
SMART
 SM00248; ANK 
PROSITE
 PS50297; ANK_REP_REGION
 PS50088; ANK_REPEAT 
PRINTS
 PR01415; ANKYRIN.