CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-042009
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cisplatin resistance related protein CRR9p, isoform CRA_c 
Protein Synonyms/Alias
 Cleft lip and palate transmembrane protein 1-like protein 
Gene Name
 CLPTM1L 
Gene Synonyms/Alias
 CRR9; hCG_1810932 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
66ADVHRYMKMIQLGKTubiquitination[1, 2, 3]
72MKMIQLGKTVHYLPIubiquitination[3]
90DQLSNRVKDLMVINRubiquitination[3]
110PLTVSYDKVSLGRLRubiquitination[1, 2, 3, 4, 5]
183ISFWKKKKSMIGMSTubiquitination[3]
290LFVNYKLKSVAHLPWubiquitination[1, 4]
298SVAHLPWKAFTYKAFubiquitination[1, 3, 4]
348RWLYPVDKRRVNEFGubiquitination[2, 3, 4]
361FGESYEEKATRAPHTubiquitination[2, 3, 4, 5, 6]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [6] Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level.
 Danielsen JM, Sylvestersen KB, Bekker-Jensen S, Szklarczyk D, Poulsen JW, Horn H, Jensen LJ, Mailand N, Nielsen ML.
 Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. [PMID: 21139048
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 369 AA 
Protein Sequence
MVPKPEEINL LTGESDTQQI EAEKKPTSAL DEPVSHWRPR LALNVMADNF VFDGSSLPAD 60
VHRYMKMIQL GKTVHYLPIL FIDQLSNRVK DLMVINRSTT ELPLTVSYDK VSLGRLRFWI 120
HMQDAVYSLQ QFGFSEKDAD EVKGIFVDTN LYFLALTFFV AAFHLLFDFL AFKNDISFWK 180
KKKSMIGMST KLWKVKKALK MTIFWRGLMP EFQFGTYSES ERKTEEYDTQ AMKYLSYLLY 240
PLCVGGAVYS LLNIKYKSWY SWLINSFVNG VYAFGFLFML PQLFVNYKLK SVAHLPWKAF 300
TYKAFNTFID DVFAFIITMP TSHRLACFRD DVVFLVYLYQ RWLYPVDKRR VNEFGESYEE 360
KATRAPHTD 369 
Gene Ontology
  
Interpro
 IPR008429; CLPTM1. 
Pfam
 PF05602; CLPTM1 
SMART
  
PROSITE
  
PRINTS