UniProt Accession

 OST2_YEAST; P46964; D6W2G3 

Genbank Protein ID

 U32307; X94335; Z75010; BK006948 

Genbank Nucleotide ID

 AAC49086.1; CAA64024.1; CAA99300.1; DAA10879.1 

Protein Name

 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST2 

Protein Synonyms/Alias

 Oligosaccharyl transferase subunit OST2; Oligosaccharyl transferase 16 kDa subunit; Oligosaccharyl transferase subunit epsilon 

Gene Name

 OST2 

Gene Synonyms/Alias

 YOR103C; YOR3211C 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
40	AYFAQIEKYPKLKLI	acetylation	[1]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 

Functional Description

 Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. 

Sequence Annotation

  

Keyword

 Complete proteome; Direct protein sequencing; Endoplasmic reticulum; Glycosyltransferase; Membrane; Reference proteome; Transferase; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 130 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; ISM:SGD.
 GO:0008250; C:oligosaccharyltransferase complex; IPI:SGD.
 GO:0004579; F:dolichyl-diphosphooligosaccharide-protein glycotransferase activity; IPI:SGD.
 GO:0006487; P:protein N-linked glycosylation; IMP:SGD. 

Interpro

 IPR003038; DAD/Ost2. 

Pfam

 PF02109; DAD 

SMART

  

PROSITE

  

PRINTS