| Tag | Content |
|---|
| CPLM ID | CPLM-018712 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Structural maintenance of chromosomes protein 6 |
Protein Synonyms/Alias | SMC protein 6; SMC-6; mSMC6 |
Gene Name | Smc6 |
Gene Synonyms/Alias | Kiaa4103; Smc6l1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 5 | ***MAKRKEENFCSP | acetylation | [1] |
|
Reference | [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways. Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y. Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [ PMID: 22826441] |
Functional Description | Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components (By similarity). |
Sequence Annotation | NP_BIND 82 89 ATP (Potential).
REGION 458 667 Flexible hinge.
MOD_RES 675 675 Phosphoserine (By similarity). |
Keyword | Alternative splicing; ATP-binding; Chromosome; Coiled coil; Complete proteome; DNA damage; DNA recombination; DNA repair; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Telomere; Ubl conjugation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1097 AA |
Protein Sequence | MAKRKEENFC SPENAKRPRQ EELEDFDKDG DEDECTISFT NGTSTLTAAE VGIIESIQLR 60
NFMCHSMLGP FKFGSNVNFV VGNNGSGKSA VLTALIVGLG GKAVATNRGS SLKGFVKAGQ 120
NSADISITLR NRGDDAFRAN VYGDSIVVQQ HISVDGSRSY KLKSEKGTVV STRKEELIAI 180
LDHFNIQVDN PVSVLTQEMS KQFLQSKNEG DKYKFFMKAT QLEQMKEDYS YIMETKERTK 240
EQINQGEERL TELKRQCLEK EERFQNIAGL STMKTNLEYL KHEMAWAVVN EIEKQLNAIR 300
DNIKIGEERA AKLDRKMEEQ QVRLNDAEKK YKDIQDKLEK ISEETNARAP ECMALKTDVI 360
ARTRAFNDAE VLYNRSLNEY KALKKDGEQL CKRIEELKKS TDQSLEPERL ERQKRICWLK 420
EKVKALQDQE HTVNQEAEQF EQAIEKDKQE HGRVRKEDIE VRHALNYNQR QLKELKDSKT 480
DRLKRFGPHV PALLEAIDDA YRRRQFTHKP IGPLGACIHL RDPELALAIE SCLKGLLQAY 540
CCHNHADERV LQSLMKKFYP PGTSRPQIIV SEFRDEVYDV RLRAAYHPEF PTVLTALEID 600
NAVVANSLID MRSIETVLLI KNNSVARAVM QSQKPPKNCR EAFTADGDQV FAGRYYSSES 660
TRPKFLSRDV DSEISDLETE IENKKGHIIT LQQRLSALEK DIKRNEELLK RCQLHYKEIK 720
MKIRKNISEI RELENIEEHQ SVDIATLEDE AEENKIKMQM VEKNMEQQKE NMENLKSLKI 780
EAENKYDTIK LKINQLSELA DPLKDELNLA DSEVDSQKRG KQHYEDKQKE HLDTLNKKRR 840
ELDMKEKELQ EKMSQARQIC PERIEVKKSA SILDKEINRL RQKIQAEHAS HGDREEIMKQ 900
YQEARETYLD LDNKVRTLRR FIKLLEEIMT HRYKTYQQFR RCLTLRCKLY FDNLLSQRAY 960
CGKMNFDHKN ETLSITVQPG EGNKASFNDM RALSGGERSF STVCFILSLW SIAESPFRCL 1020
DEFDVYMDMV NRRIAMDMIL KMADSQRFRQ FILLTPQSMS SLPSSKLIRI LRMSDPERGQ 1080
TTLPFRPVTQ EEDDSAS 1097 |
Gene Ontology | GO:0000781; C:chromosome, telomeric region; ISS:UniProtKB. GO:0016605; C:PML body; ISS:UniProtKB. GO:0030915; C:Smc5-Smc6 complex; ISS:UniProtKB. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0090398; P:cellular senescence; ISS:UniProtKB. GO:0000724; P:double-strand break repair via homologous recombination; IEA:InterPro. GO:0000722; P:telomere maintenance via recombination; ISS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |