UniProt Accession

 PDK1_MOUSE; Q8BFP9; Q3U5E5 

Genbank Protein ID

 AK046805; AK153649; AL928963; CH466519; CH466519; CH466519 

Genbank Nucleotide ID

 BAC32879.1; BAE32134.1; CAM26372.1; EDL27100.1; EDL27102.1; EDL27104.1 

Protein Name

 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial 

Protein Synonyms/Alias

 Pyruvate dehydrogenase kinase isoform 1; PDH kinase 1 

Gene Name

 Pdk1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
403	ERLPVYNKAAWKHYK	acetylation	[1]
403	ERLPVYNKAAWKHYK	succinylation	[1]

Reference

 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 Serine/threonine kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress (By similarity). 

Sequence Annotation

 DOMAIN 161 391 Histidine kinase.
 NP_BIND 277 284 ATP (By similarity).
 NP_BIND 335 336 ATP (By similarity).
 NP_BIND 352 357 ATP (By similarity).
 BINDING 316 316 ATP (By similarity).
 MOD_RES 136 136 Phosphotyrosine; by FGFR1 (By
 MOD_RES 241 241 Phosphotyrosine; by FGFR1, ABL1, FLT3 and
 MOD_RES 242 242 Phosphotyrosine; by FGFR1 (By  

Keyword

 ATP-binding; Carbohydrate metabolism; Complete proteome; Glucose metabolism; Kinase; Mitochondrion; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 434 AA 

Protein Sequence

Gene Ontology

 GO:0005967; C:mitochondrial pyruvate dehydrogenase complex; IDA:UniProtKB.
 GO:0005886; C:plasma membrane; ISA:MGI.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
 GO:0004740; F:pyruvate dehydrogenase (acetyl-transferring) kinase activity; ISS:UniProtKB.
 GO:0008283; P:cell proliferation; ISS:UniProtKB.
 GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW.
 GO:0097411; P:hypoxia-inducible factor-1alpha signaling pathway; ISS:UniProtKB.
 GO:0008631; P:intrinsic apoptotic signaling pathway in response to oxidative stress; ISS:UniProtKB.
 GO:0010510; P:regulation of acetyl-CoA biosynthetic process from pyruvate; IMP:UniProtKB.
 GO:0010906; P:regulation of glucose metabolic process; ISS:UniProtKB. 

Interpro

 IPR018955; BCDHK/PDK_N.
 IPR003594; HATPase_ATP-bd.
 IPR005467; Sig_transdc_His_kinase_core. 

Pfam

 PF10436; BCDHK_Adom3
 PF02518; HATPase_c 

SMART

 SM00387; HATPase_c 

PROSITE

 PS50109; HIS_KIN 

PRINTS