UniProt Accession

 ELP3_MOUSE; Q9CZX0; Q8C2K2; Q8R369 

Genbank Protein ID

 AK012072; AK088457; BC026461; BC057453 

Genbank Nucleotide ID

 BAB28009.1; BAC40364.1; AAH26461.1; AAH57453.1 

Protein Name

 Elongator complex protein 3 

Protein Synonyms/Alias

  

Gene Name

 Elp3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
34	VEAHEQGKDVDLNKM	ubiquitination	[1]
40	GKDVDLNKMKTKTAA	ubiquitination	[1]
48	MKTKTAAKYGLASQP	ubiquitination	[1]
280	LAKDSGFKVVTHMMP	acetylation	[2]
333	TGLYELWKSGRYRSY	ubiquitination	[1]
392	ELAFARMKDLGIQCR	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

 Catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. May also have a methyltransferase activity. Involved in cell migration. 

Sequence Annotation

 DOMAIN 396 547 N-acetyltransferase.
 METAL 99 99 Iron-sulfur (4Fe-4S-S-AdoMet) (By
 METAL 109 109 Iron-sulfur (4Fe-4S-S-AdoMet) (By
 METAL 112 112 Iron-sulfur (4Fe-4S-S-AdoMet) (By  

Keyword

 Acyltransferase; Alternative splicing; Complete proteome; Cytoplasm; Iron; Iron-sulfur; Metal-binding; Nucleus; Reference proteome; S-adenosyl-L-methionine; Transcription; Transcription regulation; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 547 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; ISS:UniProtKB.
 GO:0016591; C:DNA-directed RNA polymerase II, holoenzyme; IEA:Compara.
 GO:0033588; C:Elongator holoenzyme complex; ISS:UniProtKB.
 GO:0005730; C:nucleolus; IEA:Compara.
 GO:0008023; C:transcription elongation factor complex; ISS:UniProtKB.
 GO:0003677; F:DNA binding; IEA:Compara.
 GO:0004402; F:histone acetyltransferase activity; IEA:EC.
 GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0008607; F:phosphorylase kinase regulator activity; ISS:UniProtKB.
 GO:0016573; P:histone acetylation; IEA:GOC.
 GO:0030335; P:positive regulation of cell migration; IMP:UniProtKB.
 GO:0006357; P:regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.
 GO:0006368; P:transcription elongation from RNA polymerase II promoter; IEA:Compara. 

Interpro

 IPR016181; Acyl_CoA_acyltransferase.
 IPR006638; Elp3/MiaB/NifB.
 IPR000182; GNAT_dom.
 IPR005910; Hist_AcTrfase_ELP3.
 IPR007197; rSAM.
 IPR023404; rSAM_horseshoe. 

Pfam

 PF00583; Acetyltransf_1
 PF04055; Radical_SAM 

SMART

 SM00729; Elp3 

PROSITE

 PS51186; GNAT 

PRINTS