CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019807
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 AT-rich interactive domain-containing protein 3A 
Protein Synonyms/Alias
 ARID domain-containing protein 3A; B-cell regulator of IgH transcription; Bright; Dead ringer-like protein 1; E2F-binding protein 1 
Gene Name
 ARID3A 
Gene Synonyms/Alias
 DRIL1; DRIL3; DRX; E2FBP1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
398ITPAPKIKKEEDSAIsumoylation[1]
462SAEPPEKKMALVADEubiquitination[2]
Reference
 [1] SUMOylation of DRIL1 directs its transcriptional activity towards leukocyte lineage-specific genes.
 Prieur A, Nacerddine K, van Lohuizen M, Peeper DS.
 PLoS One. 2009;4(5):e5542. [PMID: 19436740]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Transcription factor which may be involved in the control of cell cycle progression by the RB1/E2F1 pathway and in B-cell differentiation. 
Sequence Annotation
 DOMAIN 238 330 ARID.
 DOMAIN 444 541 REKLES.
 REGION 119 156 Acidic.
 REGION 445 488 Important for nuclear localization (By
 REGION 490 513 Homodimerization.
 REGION 537 557 Important for cytoplasmic localization
 MOD_RES 77 77 Phosphoserine.
 MOD_RES 81 81 Phosphoserine.
 MOD_RES 88 88 Phosphoserine.
 MOD_RES 98 98 Phosphothreonine.
 MOD_RES 101 101 Phosphoserine.
 MOD_RES 119 119 Phosphoserine.  
Keyword
 3D-structure; Complete proteome; Cytoplasm; DNA-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 593 AA 
Protein Sequence
MKLQAVMETL LQRQQRARQE LEARQQLPPD PPAAPPGRAR AAPDEDREPE SARMQRAQMA 60
ALAAMRAAAA GLGHPASPGG SEDGPPGSEE EDAAREGTPG SPGRGREGPG EEHFEDMASD 120
EDMKPKWEEE EMEEDLGEDE EEEEEDYEDE EEEEDEEGLG PPGPASLGTT ALFPRKAQPP 180
QAFRGDGVPR VLGGQERPGP GPAHPGGAAH VAPQLQPPDH GDWTYEEQFK QLYELDGDPK 240
RKEFLDDLFS FMQKRGTPVN RIPIMAKQVL DLFMLYVLVT EKGGLVEVIN KKLWREITKG 300
LNLPTSITSA AFTLRTQYMK YLYPYECEKR GLSNPNELQA AIDSNRREGR RQSFGGSLFA 360
YSPGGAHGML SSPKLPVSSL GLAASTNGSS ITPAPKIKKE EDSAIPITVP GRLPVSLAGH 420
PVVAAQAAAV QAAAAQAAVA AQAAALEQLR EKLESAEPPE KKMALVADEQ QRLMQRALQQ 480
NFLAMAAQLP MSIRINSQAS ESRQDSAVNL TGTNGSNSIS MSVEINGIMY TGVLFAQPPA 540
PTPTSAPNKG GGGGGGSSSN AGGRGGNTGT SGGQAGPAGL STPSTSTSNN SLP 593 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0045121; C:membrane raft; IDA:MGI.
 GO:0005634; C:nucleus; NAS:UniProtKB.
 GO:0003682; F:chromatin binding; IEA:Compara.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; NAS:UniProtKB.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR001606; ARID/BRIGHT_DNA-bd.
 IPR023334; REKLES_domain. 
Pfam
 PF01388; ARID 
SMART
 SM00501; BRIGHT 
PROSITE
 PS51011; ARID
 PS51486; REKLES 
PRINTS