UniProt Accession

 PP14A_RAT; Q99MC0 

Genbank Protein ID

 AF352572; AY050673 

Genbank Nucleotide ID

 AAK35213.1; AAL25831.1 

Protein Name

 Protein phosphatase 1 regulatory subunit 14A 

Protein Synonyms/Alias

 17 kDa PKC-potentiated inhibitory protein of PP1; Protein kinase C-potentiated inhibitor protein of 17 kDa; CPI-17 

Gene Name

 Ppp1r14a 

Gene Synonyms/Alias

 Cpi; Cpi17 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
40	RHARVTVKYDRRELQ	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction (By similarity). 

Sequence Annotation

 REGION 35 120 Inhibitory.
 MOD_RES 26 26 Phosphoserine (By similarity).
 MOD_RES 38 38 Phosphothreonine (By similarity).
 MOD_RES 128 128 Phosphoserine (By similarity).
 MOD_RES 130 130 Phosphoserine (By similarity).
 MOD_RES 134 134 Phosphoserine (By similarity).
 MOD_RES 136 136 Phosphoserine (By similarity).  

Keyword

 Complete proteome; Cytoplasm; Phosphoprotein; Protein phosphatase inhibitor; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 147 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0004864; F:protein phosphatase inhibitor activity; TAS:RGD.
 GO:0042325; P:regulation of phosphorylation; IEA:InterPro. 

Interpro

 IPR008025; PP1_inhibitor. 

Pfam

 PF05361; PP1_inhibitor 

SMART

  

PROSITE

  

PRINTS