CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000566
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Dynamin-1-like protein 
Protein Synonyms/Alias
 Dynamin-like protein 
Gene Name
 Dnm1l 
Gene Synonyms/Alias
 Dlp1 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
173VPVGDQPKDIELQIRubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
 Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into ring-like structures which wrap around the scission site to constict and sever the mitochondrial membrane through a GTP hydrolysis- dependent mechanism. Required for normal brain development. Facilitates developmentally-regulated apoptosis during neural tube development. Required for a normal rate of cytochrome c release and caspase activation during apoptosis. May be involved in vesicle transport (By similarity). Required for programmed necrosis execution (By similarity). Also required for mitochondrial fission during mitosis. 
Sequence Annotation
 DOMAIN 663 754 GED.
 NP_BIND 32 39 GTP (By similarity).
 NP_BIND 159 163 GTP (By similarity).
 NP_BIND 228 231 GTP (By similarity).
 REGION 1 356 GTPase domain (By similarity).
 REGION 1 356 N-terminal dimerization domain (By
 REGION 357 502 Middle domain (By similarity).
 REGION 461 704 Interaction with GSK3B (By similarity).
 REGION 461 667 Interaction with GSK3B (By similarity).
 REGION 515 582 B domain (By similarity).
 REGION 555 755 C-terminal dimerization domain (By
 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 542 542 Phosphoserine (By similarity).
 MOD_RES 561 561 Phosphoserine (By similarity).
 MOD_RES 626 626 Phosphoserine (By similarity).
 MOD_RES 635 635 Phosphoserine; by CDK1.
 MOD_RES 656 656 Phosphoserine; by CAMK1 and PKA (By
 MOD_RES 663 663 S-nitrosocysteine (By similarity).
 CARBOHYD 604 604 O-linked (GlcNAc...).
 CARBOHYD 605 605 O-linked (GlcNAc...).
 CROSSLNK 545 545 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 548 548 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 571 571 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 581 581 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 613 613 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 616 616 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 625 625 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 627 627 Glycyl lysine isopeptide (Lys-Gly)  
Keyword
 Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Glycoprotein; Golgi apparatus; GTP-binding; Hydrolase; Isopeptide bond; Membrane; Mitochondrion; Mitochondrion outer membrane; Necrosis; Nucleotide-binding; Phosphoprotein; Reference proteome; S-nitrosylation; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 755 AA 
Protein Sequence
MEALIPVINK LQDVFNTVGA DIIQLPQIVV VGTQSSGKSS VLESLVGRDL LPRGTGVVTR 60
RPLILQLVHV SPEDKRKTTG EENDPATWKN SRHLSKGVEA EEWGKFLHTK NKLYTDFDEI 120
RQEIENETER ISGNNKGVSP EPIHLKVFSP NVVNLTLVDL PGMTKVPVGD QPKDIELQIR 180
ELILRFISNP NSIILAVTAA NTDMATSEAL KISREVDPDG RRTLAVITKL DLMDAGTDAM 240
DVLMGRVIPV KLGIIGVVNR SQLDINNKKS VTDSIRDEYA FLQKKYPSLA NRNGTKYLAR 300
TLNRLLMHHI RDCLPELKTR INVLAAQYQS LLNSYGEPVD DKSATLLQLI TKFATEYCNT 360
IEGTAKYIET SELCGGARIC YIFHETFGRT LESVDPLGGL NTIDILTAIR NATGPRPALF 420
VPEVSFELLV KRQIKRLEEP SLRCVELVHE EMQRIIQHCS NYSTQELLRF PKLHDAIVEV 480
VTCLLRKRLP VTNEMVHNLV AIELAYINTK HPDFADACGL MNNNIEEQRR NRLARELPSA 540
VSRDKSSKVP SALAPASQEP SPAASAEADG KLIQDNRRET KNVASAGGGI GDGGRIGDGG 600
QEPTTGNWRG MLKTSKAEEL LAEEKSKPIP IMPASPQKGH AVNLLDVPVP VARKLSAREQ 660
RDCEVIERLI KSYFLIVRKN IQDSVPKAVM HFLVNHVKDT LQSELVGQLY KSSLLDDLLT 720
ESEDMAQRRK EAADMLKALQ GASQIIAEIR ETHLW 755 
Gene Ontology
 GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
 GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
 GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
 GO:0005874; C:microtubule; IEA:Compara.
 GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0005777; C:peroxisome; IEA:Compara.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003924; F:GTPase activity; IEA:InterPro.
 GO:0003374; P:dynamin polymerization involved in mitochondrial fission; IEA:Compara.
 GO:0006184; P:GTP catabolic process; IEA:GOC.
 GO:0090149; P:membrane fission involved in mitochondrial fission; IEA:Compara.
 GO:0043653; P:mitochondrial fragmentation involved in apoptotic process; IEA:Compara.
 GO:0070584; P:mitochondrion morphogenesis; IEA:Compara.
 GO:0016559; P:peroxisome fission; IEA:Compara.
 GO:2001244; P:positive regulation of intrinsic apoptotic signaling pathway; IEA:Compara.
 GO:0050714; P:positive regulation of protein secretion; IEA:Compara.
 GO:0090200; P:positive regulation of release of cytochrome c from mitochondria; IEA:Compara.
 GO:0051289; P:protein homotetramerization; IEA:Compara.
 GO:1900063; P:regulation of peroxisome organization; IEA:Compara. 
Interpro
 IPR022812; Dynamin.
 IPR000375; Dynamin_central.
 IPR001401; Dynamin_GTPase.
 IPR019762; Dynamin_GTPase_CS.
 IPR003130; GED.
 IPR020850; GTPase_effector_domain_GED.
 IPR027417; P-loop_NTPase. 
Pfam
 PF01031; Dynamin_M
 PF00350; Dynamin_N
 PF02212; GED 
SMART
 SM00053; DYNc
 SM00302; GED 
PROSITE
 PS00410; DYNAMIN
 PS51388; GED 
PRINTS
 PR00195; DYNAMIN.