CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024983
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cyclin-dependent kinase 7 
Protein Synonyms/Alias
 IP01401p 
Gene Name
 Cdk7 
Gene Synonyms/Alias
 CG3319; Dmel_CG3319 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
328NPQTGDTKPALKRKLacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Cyclin; Kinase; Nucleotide-binding; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 353 AA 
Protein Sequence
MLPNANDKTE RYAKLSFLGE GQFATVYKAR DTVTNQIVAV KKIKKGSRED ARDGINRTAL 60
REIKILQELQ HENIIGLVDV FGQLSNVSLV FDFMDTDLEV IIKDNKIILT QANIKAYAIM 120
TLKGLEYLHL NWILHRDLKP NNLLVNSDGI LKIGDFGLAK SFGSPNRIYT HHVVTRWYRS 180
PELLFGARQY GTGVDMWAVG CILAELMLRV PFMPGDSDLD QLTRIFSTLG TPTEAEWPHL 240
SKLHDYLQFR NFPGTPLDNI FTAAGNDLIH LMQRLFAMNP LRRVSCREAL SMPYFANKPA 300
PTVGPKLPMP SAILAAKEGA NPQTGDTKPA LKRKLVETTV RGNGLAQKKR LQF 353 
Gene Ontology
 GO:0032806; C:carboxy-terminal domain protein kinase complex; IDA:FlyBase.
 GO:0005737; C:cytoplasm; IDA:FlyBase.
 GO:0005675; C:holo TFIIH complex; IDA:FlyBase.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004693; F:cyclin-dependent protein serine/threonine kinase activity; ISS:FlyBase.
 GO:0008353; F:RNA polymerase II carboxy-terminal domain kinase activity; IEA:EC.
 GO:0007067; P:mitosis; IMP:FlyBase.
 GO:0001111; P:promoter clearance from RNA polymerase II promoter; IDA:FlyBase.
 GO:0000079; P:regulation of cyclin-dependent protein serine/threonine kinase activity; IDA:FlyBase.
 GO:0006367; P:transcription initiation from RNA polymerase II promoter; ISS:FlyBase. 
Interpro
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 
Pfam
 PF00069; Pkinase 
SMART
 SM00220; S_TKc 
PROSITE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS